A neuroendocrine view of ECT

M. Fink, C. B. Nemeroff

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptide antidepressin - the active principle that relieves both neuroendocrine and behavioral abnormalities.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalConvulsive Therapy
Issue number3
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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