A natural peptide with NMDA inhibitory activity reduces tonic pain in the formalin model

Julie B. Siegan, Jacqueline Sagen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

THE aim of this study was to assess whether a natural peptide, histogranin, isolated from chromaffin cells and possessing NMDA receptor inhibitory activity, could reduce tonic pain. Rats received intrathecal injections of the stable analog [Ser1]histogranin (SHG), prior to induction of the formalin response. SHG markedly suppressed the second tonic phase of the formalin response compared with saline vehicle. A U-shaped dose-response curve was obtained. SHG had no effect on phase 1 acute pain responses. These findings indicate that SHG acts in a similar fashion as other, non-peptide, NMDA antagonists in suppressing tonic, but not acute pain. The presence of the natural peptide in chromaffin cells may contribute to the analgesic effects of adrenal medullary implants.

Original languageEnglish
Pages (from-to)1379-1381
Number of pages3
JournalNeuroReport
Volume8
Issue number6
StatePublished - Jun 21 1997
Externally publishedYes

Fingerprint

N-Methylaspartate
Formaldehyde
Pain
Peptides
Chromaffin Cells
Acute Pain
Spinal Injections
N-Methyl-D-Aspartate Receptors
Analgesics
histogranin

Keywords

  • Adrenal medulla
  • Analgesia
  • Chromaffin cells
  • Chronic pain
  • Neuropeptides
  • NMDA antagonists
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A natural peptide with NMDA inhibitory activity reduces tonic pain in the formalin model. / Siegan, Julie B.; Sagen, Jacqueline.

In: NeuroReport, Vol. 8, No. 6, 21.06.1997, p. 1379-1381.

Research output: Contribution to journalArticle

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