A natural peptide with NMDA inhibitory activity reduces tonic pain in the formalin model

Julie B. Siegan, Jacqueline Sagen

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

THE aim of this study was to assess whether a natural peptide, histogranin, isolated from chromaffin cells and possessing NMDA receptor inhibitory activity, could reduce tonic pain. Rats received intrathecal injections of the stable analog [Ser1]histogranin (SHG), prior to induction of the formalin response. SHG markedly suppressed the second tonic phase of the formalin response compared with saline vehicle. A U-shaped dose-response curve was obtained. SHG had no effect on phase 1 acute pain responses. These findings indicate that SHG acts in a similar fashion as other, non-peptide, NMDA antagonists in suppressing tonic, but not acute pain. The presence of the natural peptide in chromaffin cells may contribute to the analgesic effects of adrenal medullary implants.

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalNeuroreport
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Adrenal medulla
  • Analgesia
  • Chromaffin cells
  • Chronic pain
  • Neuropeptides
  • NMDA antagonists
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A natural peptide with NMDA inhibitory activity reduces tonic pain in the formalin model'. Together they form a unique fingerprint.

  • Cite this