A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma

Tamar Stone; Alexandra Berger; Sheila Blumberg; Daniel O'Neill; Frank Ross; Alexander Mcmeeking; Weiliam Chen; Irena Pastar

doi:10.1111/j.1742-481X.2011.00887.x

A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma

Tamar Stone, Alexandra Berger, Sheila Blumberg, Daniel O'Neill, Frank Ross, Alexander Mcmeeking, Weiliam Chen, Irena Pastar

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.

Original language	English (US)
Pages (from-to)	324-329
Number of pages	6
Journal	International Wound Journal
Volume	9
Issue number	3
DOIs	https://doi.org/10.1111/j.1742-481X.2011.00887.x
State	Published - Jun 1 2012
Externally published	Yes

Keywords

Hydroxyurea
Non healing wound
Polycythemia vera
Squamous cell carcinoma

ASJC Scopus subject areas

Surgery
Dermatology

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Stone, T., Berger, A., Blumberg, S., O'Neill, D., Ross, F., Mcmeeking, A., Chen, W., & Pastar, I. (2012). A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma. International Wound Journal, 9(3), 324-329. https://doi.org/10.1111/j.1742-481X.2011.00887.x

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abstract = "Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.",

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AU - Chen, Weiliam

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AB - Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.

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