A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma

Tamar Stone, Alexandra Berger, Sheila Blumberg, Daniel O'Neill, Frank Ross, Alexander Mcmeeking, Weiliam Chen, Irena Pastar

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.

Original languageEnglish (US)
Pages (from-to)324-329
Number of pages6
JournalInternational Wound Journal
Volume9
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Keywords

  • Hydroxyurea
  • Non healing wound
  • Polycythemia vera
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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