A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation

Ling Jia Wang, Tatsuya Kin, Doug O’Gorman, A. M James Shapiro, Bashoo Naziruddin, Morihito Takita, Marlon F. Levy, Andrew M. Posselt, Gregory L. Szot, Omid Savari, Barbara Barbaro, James McGarrigle, Chunchieh Yeh, Jose Oberholzer, Ji Lei, Tao Chen, Moh Lian, James F. Markmann, Alejandro Alvarez, Elina LinetskyCamillo Ricordi, A. N. Balamurugan, Gopalakrishnan Loganathan, Joshua J. Wilhelm, Bernhard J. Hering, Rita Bottino, Massimo Trucco, Chengyang Liu, Zaw Min, Yanjing Li, Ali Naji, Luis A. Fernandez, Martynas Ziemelis, Juan S. Danobeitia, J. Michael Millis, Piotr Witkowski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70–0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.

Original languageEnglish (US)
Pages (from-to)1515-1523
Number of pages9
JournalCell Transplantation
Volume25
Issue number8
DOIs
StatePublished - 2016

Fingerprint

Donor Selection
Islets of Langerhans Transplantation
Multicenter Studies
Logistics
Pancreas
Decision making
North America
Retrospective Studies
Logistic Models
Regression Analysis
Confidence Intervals
Research
Datasets

Keywords

  • Islet isolation
  • Islet transplantation
  • Organ donor
  • Pancreas

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

Cite this

Wang, L. J., Kin, T., O’Gorman, D., Shapiro, A. M. J., Naziruddin, B., Takita, M., ... Witkowski, P. (2016). A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation. Cell Transplantation, 25(8), 1515-1523. https://doi.org/10.3727/096368916X691141

A multicenter study : North american islet donor score in donor pancreas selection for human islet isolation for transplantation. / Wang, Ling Jia; Kin, Tatsuya; O’Gorman, Doug; Shapiro, A. M James; Naziruddin, Bashoo; Takita, Morihito; Levy, Marlon F.; Posselt, Andrew M.; Szot, Gregory L.; Savari, Omid; Barbaro, Barbara; McGarrigle, James; Yeh, Chunchieh; Oberholzer, Jose; Lei, Ji; Chen, Tao; Lian, Moh; Markmann, James F.; Alvarez, Alejandro; Linetsky, Elina; Ricordi, Camillo; Balamurugan, A. N.; Loganathan, Gopalakrishnan; Wilhelm, Joshua J.; Hering, Bernhard J.; Bottino, Rita; Trucco, Massimo; Liu, Chengyang; Min, Zaw; Li, Yanjing; Naji, Ali; Fernandez, Luis A.; Ziemelis, Martynas; Danobeitia, Juan S.; Millis, J. Michael; Witkowski, Piotr.

In: Cell Transplantation, Vol. 25, No. 8, 2016, p. 1515-1523.

Research output: Contribution to journalArticle

Wang, LJ, Kin, T, O’Gorman, D, Shapiro, AMJ, Naziruddin, B, Takita, M, Levy, MF, Posselt, AM, Szot, GL, Savari, O, Barbaro, B, McGarrigle, J, Yeh, C, Oberholzer, J, Lei, J, Chen, T, Lian, M, Markmann, JF, Alvarez, A, Linetsky, E, Ricordi, C, Balamurugan, AN, Loganathan, G, Wilhelm, JJ, Hering, BJ, Bottino, R, Trucco, M, Liu, C, Min, Z, Li, Y, Naji, A, Fernandez, LA, Ziemelis, M, Danobeitia, JS, Millis, JM & Witkowski, P 2016, 'A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation', Cell Transplantation, vol. 25, no. 8, pp. 1515-1523. https://doi.org/10.3727/096368916X691141
Wang, Ling Jia ; Kin, Tatsuya ; O’Gorman, Doug ; Shapiro, A. M James ; Naziruddin, Bashoo ; Takita, Morihito ; Levy, Marlon F. ; Posselt, Andrew M. ; Szot, Gregory L. ; Savari, Omid ; Barbaro, Barbara ; McGarrigle, James ; Yeh, Chunchieh ; Oberholzer, Jose ; Lei, Ji ; Chen, Tao ; Lian, Moh ; Markmann, James F. ; Alvarez, Alejandro ; Linetsky, Elina ; Ricordi, Camillo ; Balamurugan, A. N. ; Loganathan, Gopalakrishnan ; Wilhelm, Joshua J. ; Hering, Bernhard J. ; Bottino, Rita ; Trucco, Massimo ; Liu, Chengyang ; Min, Zaw ; Li, Yanjing ; Naji, Ali ; Fernandez, Luis A. ; Ziemelis, Martynas ; Danobeitia, Juan S. ; Millis, J. Michael ; Witkowski, Piotr. / A multicenter study : North american islet donor score in donor pancreas selection for human islet isolation for transplantation. In: Cell Transplantation. 2016 ; Vol. 25, No. 8. pp. 1515-1523.
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AU - Wang, Ling Jia

AU - Kin, Tatsuya

AU - O’Gorman, Doug

AU - Shapiro, A. M James

AU - Naziruddin, Bashoo

AU - Takita, Morihito

AU - Levy, Marlon F.

AU - Posselt, Andrew M.

AU - Szot, Gregory L.

AU - Savari, Omid

AU - Barbaro, Barbara

AU - McGarrigle, James

AU - Yeh, Chunchieh

AU - Oberholzer, Jose

AU - Lei, Ji

AU - Chen, Tao

AU - Lian, Moh

AU - Markmann, James F.

AU - Alvarez, Alejandro

AU - Linetsky, Elina

AU - Ricordi, Camillo

AU - Balamurugan, A. N.

AU - Loganathan, Gopalakrishnan

AU - Wilhelm, Joshua J.

AU - Hering, Bernhard J.

AU - Bottino, Rita

AU - Trucco, Massimo

AU - Liu, Chengyang

AU - Min, Zaw

AU - Li, Yanjing

AU - Naji, Ali

AU - Fernandez, Luis A.

AU - Ziemelis, Martynas

AU - Danobeitia, Juan S.

AU - Millis, J. Michael

AU - Witkowski, Piotr

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