A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation

Andrea Szigeti, Erika Tátrai, Anna Szamosi, Péter Vargha, Zoltán Zsolt Nagy, János Németh, Delia Cabrera DeBuc, Gábor Márk Somfai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: The purpose of this study was to evaluate the possible structural changes of the macula in patients with unilateral amblyopia using optical coherence tomography (OCT) image segmentation. Patients and Methods: 38 consecutive patients (16 male; mean age 32.4±17.6 years; range 6-67 years) with unilateral amblyopia were involved in this study. OCT examinations were performed with a time-domain OCT device, and a custombuilt OCT image analysis software (OCTRIMA) was used for OCT image segmentation. The axial length (AL) was measured by a LenStar LS 900 device. Macular layer thickness, AL and manifest spherical equivalent refraction (MRSE) of the amblyopic eye were compared to that of the fellow eye. We studied if the type of amblyopia (strabismus without anisometropia, anisometropia without strabismus, strabismus with anisometropia) had any influence on macular layer thickness values. Results: There was significant difference between the amblyopic and fellow eyes in MRSE and AL in all subgroups. Comparing the amblyopic and fellow eyes, we found a statistically significant difference only in the thickness of the outer nuclear layer in the central region using linear mixed model analysis keeping AL and age under control (p = 0.032). There was no significant difference in interocular difference in the thickness of any macular layers between the subgroups with one-way between-groups ANCOVA while statistically controlling for interocular difference in AL and age. Conclusions: According to our results there are subtle changes in amblyopic eyes affecting the outer nuclear layer of the fovea suggesting the possible involvement of the photoreceptors. However, further studies are warranted to support this hypothesis.

Original languageEnglish
Article numbere88363
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 6 2014

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Amblyopia
Optical tomography
tomography
Optical Coherence Tomography
Image segmentation
eyes
Anisometropia
Strabismus
Equipment and Supplies
Refraction
photoreceptors
Image analysis
Linear Models
Software
image analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Szigeti, A., Tátrai, E., Szamosi, A., Vargha, P., Nagy, Z. Z., Németh, J., ... Somfai, G. M. (2014). A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. PLoS One, 9(2), [e88363]. https://doi.org/10.1371/journal.pone.0088363

A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. / Szigeti, Andrea; Tátrai, Erika; Szamosi, Anna; Vargha, Péter; Nagy, Zoltán Zsolt; Németh, János; Cabrera DeBuc, Delia; Somfai, Gábor Márk.

In: PLoS One, Vol. 9, No. 2, e88363, 06.02.2014.

Research output: Contribution to journalArticle

Szigeti, Andrea ; Tátrai, Erika ; Szamosi, Anna ; Vargha, Péter ; Nagy, Zoltán Zsolt ; Németh, János ; Cabrera DeBuc, Delia ; Somfai, Gábor Márk. / A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. In: PLoS One. 2014 ; Vol. 9, No. 2.
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