A monte carlo permutation approach to choosing an affection status model for bipolar affective disorder

Katy L. Simonsen, Norman L. Kaplan, Eden R. Martin

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A permutation test is proposed for assessing affection status models. The test uses marker data from regions with prior evidence of linkage to susceptibility genes, and three different test statistics are examined. We applied the test to the GAW10 data and found no evidence on chromosome 18 to reject the affection status model that groups individuals diagnosed with either bipolar I, bipolar II or unipolar. The chromosome 5 data gave similar results, and further suggested that individuals diagnosed with unipolar- single episode not be included as affected. A preliminary power study suggested that one of the proposed statistics, 5, is to be preferred in certain circumstances.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
JournalGenetic Epidemiology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 1997
Externally publishedYes

Keywords

  • Affection status model
  • Bipolar illness
  • Permutation test
  • Phenotypic variation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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