A mononuclear cell component in experimental immunological glomerulonephritis

G. F. Schreiner, R. S. Cotran, V. Pardo, E. R. Unanue

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Abstract

An accelerated form of nephrotoxic serum nephritis in the rat was examined. The experimental model consisted of preimmunization of the rat with rabbit IgG 5 days before injection of subnephrotoxic doses of rabbit anti-rat kidney serum. The immunized rats developed proteinuria during the first 24 h, increasing by 48-96 h. The early 24-h proteinuria correlated with a neutrophilic infiltration of glomeruli and with deposition of rat Ig and C. The 48- to 96-h proteinuria was associated with a glomerular infiltration by mononuclear cells and proliferation of intrinsic glomerular cells. Many of the mononuclear cells were morphologically identical to monocytes and macrophages. [3H]thymidine labeling experiments indicated that the mononuclear cells originated from dividing precursors localized outside the kidney. Preimmunized rats given systemic irradiation (the kidney being protected by a shield) showed loss of the mononuclear cell infiltrate and absence of 48- to 96-h proteinuria. The authors conclude that mononuclear phagocytes can infiltrate the kidney in immunological glomerular disease and might contribute to the functional abnormalities.

Original languageEnglish
Pages (from-to)369-384
Number of pages16
JournalJournal of Experimental Medicine
Volume147
Issue number2
StatePublished - Jan 1 1978

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Cellular Structures
Glomerulonephritis
Proteinuria
Kidney
Rabbits
Nephritis
Immune System Diseases
Phagocytes
Serum
Thymidine
Monocytes
Theoretical Models
Immunoglobulin G
Macrophages
Cell Proliferation
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Schreiner, G. F., Cotran, R. S., Pardo, V., & Unanue, E. R. (1978). A mononuclear cell component in experimental immunological glomerulonephritis. Journal of Experimental Medicine, 147(2), 369-384.

A mononuclear cell component in experimental immunological glomerulonephritis. / Schreiner, G. F.; Cotran, R. S.; Pardo, V.; Unanue, E. R.

In: Journal of Experimental Medicine, Vol. 147, No. 2, 01.01.1978, p. 369-384.

Research output: Contribution to journalArticle

Schreiner, GF, Cotran, RS, Pardo, V & Unanue, ER 1978, 'A mononuclear cell component in experimental immunological glomerulonephritis', Journal of Experimental Medicine, vol. 147, no. 2, pp. 369-384.
Schreiner GF, Cotran RS, Pardo V, Unanue ER. A mononuclear cell component in experimental immunological glomerulonephritis. Journal of Experimental Medicine. 1978 Jan 1;147(2):369-384.
Schreiner, G. F. ; Cotran, R. S. ; Pardo, V. ; Unanue, E. R. / A mononuclear cell component in experimental immunological glomerulonephritis. In: Journal of Experimental Medicine. 1978 ; Vol. 147, No. 2. pp. 369-384.
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