A mononuclear cell component in experimental immunological glomerulonephritis*

George F. Schreiner, Ramzi S. Cotran, Victoriano Pardo, Emil R. Unanue

Research output: Contribution to journalArticle

216 Scopus citations

Abstract

An accelerated form of nephrotoxic serum nephritis in the rat was examined. The experimental model consisted of preimmunization of the rat with rabbit IgG 5 days before injection of subnephrotoxic doses of rabbit anti-rat kidney serum. The immunized rats developed proteinuria during the first 24 h, increasing by 48-96 h. The early 24-h proteinuria correlated with a neutrophilic infiltration of glomeruli and with deposition of rat Ig and C. The 48- to 96-h proteinuria was associated with a glomerular infiltration by mononuclear cells and proliferation of intrinsic glomerular cells. Many of the mononuclear cells were morphologically identical to monocytes and macrophages. [3H]thymidine labeling experiments indicated that the mononuclear cells originated from dividing precursors localized outside the kidney. Preimmunized rats given systemic irradiation (the kidney being protected by a shield) showed loss of the mononuclear cell infiltrate and absence of 48- to 96-h proteinuria. The authors conclude that mononuclear phagocytes can infiltrate the kidney in immunological glomerular disease and might contribute to the functional abnormalities.

Original languageEnglish (US)
Pages (from-to)369-384
Number of pages16
JournalJournal of Experimental Medicine
Volume147
Issue number2
DOIs
StatePublished - Feb 1 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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