Abstract
We isolated a monoclonal antibody which decorates the endothelial cells of normal and lymphatic vessels in formalin-fixed, paraffin-embedded tissue. In addition, the antibody recognizes a previously undescribed substance found in the basement membrane zone and subbasement membrane zone of a variety of epithelia. By ELISA assay, the antigen recognized by this monoclonal antibody is not laminin, type IV collagen or fibronectin. This antibody may be used as a diagnostic tool because it identifies an epitope in neoplasms differentiating towards endothelial cell such as angiosarcoma and Kaposi's sarcoma.
Original language | English (US) |
---|---|
Pages (from-to) | 14-23 |
Number of pages | 10 |
Journal | Journal of Vascular Research |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - 1990 |
Keywords
- basement membrane
- endothelial cell
- monoclonal antibody
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine