A monoclonal antibody which identifies an antigen in endothelial cell and epithelial basement membrane

Shinobu Matsuo, Neal S. Penneys, Jo David Fine, Steffen Gay, Mehrdad Nadji

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We isolated a monoclonal antibody which decorates the endothelial cells of normal and lymphatic vessels in formalin-fixed, paraffin-embedded tissue. In addition, the antibody recognizes a previously undescribed substance found in the basement membrane zone and subbasement membrane zone of a variety of epithelia. By ELISA assay, the antigen recognized by this monoclonal antibody is not laminin, type IV collagen or fibronectin. This antibody may be used as a diagnostic tool because it identifies an epitope in neoplasms differentiating towards endothelial cell such as angiosarcoma and Kaposi's sarcoma.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalJournal of Vascular Research
Volume27
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • basement membrane
  • endothelial cell
  • monoclonal antibody

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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