A monoclonal antibody that binds to cones

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17 Scopus citations

Abstract

A monoclonal antibody that binds to cones has been produced. This antibody, 50-1B11, binds to the outer segments of cones in rhesus monkeys. Immunohistochemical experiments indicate that 50-1B11 binds to a subset of photoreceptors, probably cones, in all vertebrate species tested thus far, including man. In vitro experiments on chicken retina indicate that the antigen is intracellular and associated with the plasma membrane, while electronmicroscopic-immunohistochemical studies demonstrate that the antigen is contained in the lamellae of the outer segments of rhesus cones.

Original languageEnglish (US)
Pages (from-to)831-836
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume27
Issue number5
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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