A molecular genetic approach to vision Research: Crystallin gene expression in the lens

Joram Piatigorsky, Jacques A. Tréton, Charles R. King, John M. Nickerson, Deborah Carper, Toshimichi Shinohara, George Inana, J. Fielding Hejtmancik, Barbara Norman

Research output: Contribution to journalArticle

Abstract

Recent work from our laboratory on the molecular genetics of the lens crystallins is reviewed briefly. Examples of how cDNA and genomic clones have been used for investigating the structure and expression of lens genes are described. Present evidence indicates that two inherited cataracts in mice may be associated with specific defects in crystallin gene expression. We anticipate that molecular genetic investigations in vision and ophthalmology will advance our basic understanding of the eye, reveal the basis of hereditary defects in the visual system, and contribute to our knowledge of the eukarvotic genome.

Original languageEnglish (US)
Pages (from-to)61-72
Number of pages12
JournalOphthalmic Genetics
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Keywords

  • Cataract
  • Cloning
  • Crystallins
  • DNA
  • Eye
  • Gene
  • Hereditary disease
  • Lens

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)

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    Piatigorsky, J., Tréton, J. A., King, C. R., Nickerson, J. M., Carper, D., Shinohara, T., Inana, G., Hejtmancik, J. F., & Norman, B. (1983). A molecular genetic approach to vision Research: Crystallin gene expression in the lens. Ophthalmic Genetics, 3(2), 61-72. https://doi.org/10.3109/13816818309007821