A Modeling Approach to Investigate Epizootic Outbreaks and Enzootic Maintenance of Rift Valley Fever Virus

Farida Chamchod, Robert Cantrell, George Cosner, Ali N. Hassan, John C Beier, Shigui Ruan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We propose a mathematical model to investigate the transmission dynamics of Rift Valley fever (RVF) virus among ruminants. Our findings indicate that in endemic areas RVF virus maintains at a very low level among ruminants after outbreaks and subsequent outbreaks may occur when new susceptible ruminants are recruited into endemic areas or abundant numbers of mosquitoes emerge when herd immunity decreases. Many factors have been shown to have impacts on the severity of RVF outbreaks; a higher probability of death due to RVF among ruminants, a higher mosquito:ruminant ratio, or a shorter lifespan of animals can amplify the magnitude of the outbreaks; vaccination helps to reduce the magnitude of RVF outbreaks and the loss of animals efficiently, and the maximum vaccination effort (a high vaccination rate and a larger number of vaccinated animals) is recommended before the commencement of an outbreak but can be reduced later during the enzootic.

Original languageEnglish (US)
Pages (from-to)2052-2072
Number of pages21
JournalBulletin of Mathematical Biology
Volume76
Issue number8
DOIs
StatePublished - Sep 1 2014

Fingerprint

Rift Valley fever virus
Vaccination
ruminant
rift zone
Viruses
Virus
Ruminants
Disease Outbreaks
Rift Valley fever
Animals
ruminants
virus
Maintenance
Rift Valley Fever
vaccination
Abundant number
Modeling
modeling
mosquito
Life Span

Keywords

  • Abnormal weather
  • Mathematical modeling
  • Optimal control
  • Rift Valley fever
  • Seasonality
  • Vaccination

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Immunology
  • Mathematics(all)
  • Computational Theory and Mathematics
  • Neuroscience(all)
  • Pharmacology

Cite this

A Modeling Approach to Investigate Epizootic Outbreaks and Enzootic Maintenance of Rift Valley Fever Virus. / Chamchod, Farida; Cantrell, Robert; Cosner, George; Hassan, Ali N.; Beier, John C; Ruan, Shigui.

In: Bulletin of Mathematical Biology, Vol. 76, No. 8, 01.09.2014, p. 2052-2072.

Research output: Contribution to journalArticle

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