Abstract
The aim of this study was to investigate the utility of distortion product otoacoustic emissions (DPOAEs) in intraoperative monitoring (IM) of cochlear ischemic episodes in animals during internal auditory artery (IAA) compression. The IAA was exposed using the posterior fossa approach and then compressed for 3 and 5 min intervals to effect ischemia. DPOAE amplitudes and phases were measured at 4, 8, and 12 kHz geometric mean frequency (GMF). In each monitored ear, laser-Doppler cochlear blood flow (CBF) was measured. All IAA compressions resulted in rapid decrease of DPOAE amplitude and CBF, with simultaneous DPOAE phase increase. DPOAE phase changes were found to increase consistently within several seconds of IAA compression, while corresponding DPOAE amplitudes changed more slowly, with up to 30-40 s delays. Following IAA release, DPOAEs at 12 kHz GMF were characterized by longer delays in returning to baseline than those measured at lower frequencies. In some cases, CBF did not return to baseline. In this animal model, DPOAEs were found to be sensitive measures of cochlear function during transient cochlear ischemic episodes, suggesting the utility of DPOAE monitoring of auditory function during surgery of cerebello-pontine angle tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 117-127 |
| Number of pages | 11 |
| Journal | Hearing Research |
| Volume | 212 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 1 2006 |
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Keywords
- Cochlear blood flow
- Cochlear ischemia
- Cochlear reperfusion
- Otoacoustic emissions
ASJC Scopus subject areas
- Sensory Systems
Cite this
A model of real time monitoring of the cochlear function during an induced local ischemia. / Morawski, Krzysztof; Telischi, Fred F; Niemczyk, Kazimierz.
In: Hearing Research, Vol. 212, No. 1-2, 01.02.2006, p. 117-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A model of real time monitoring of the cochlear function during an induced local ischemia
AU - Morawski, Krzysztof
AU - Telischi, Fred F
AU - Niemczyk, Kazimierz
PY - 2006/2/1
Y1 - 2006/2/1
N2 - The aim of this study was to investigate the utility of distortion product otoacoustic emissions (DPOAEs) in intraoperative monitoring (IM) of cochlear ischemic episodes in animals during internal auditory artery (IAA) compression. The IAA was exposed using the posterior fossa approach and then compressed for 3 and 5 min intervals to effect ischemia. DPOAE amplitudes and phases were measured at 4, 8, and 12 kHz geometric mean frequency (GMF). In each monitored ear, laser-Doppler cochlear blood flow (CBF) was measured. All IAA compressions resulted in rapid decrease of DPOAE amplitude and CBF, with simultaneous DPOAE phase increase. DPOAE phase changes were found to increase consistently within several seconds of IAA compression, while corresponding DPOAE amplitudes changed more slowly, with up to 30-40 s delays. Following IAA release, DPOAEs at 12 kHz GMF were characterized by longer delays in returning to baseline than those measured at lower frequencies. In some cases, CBF did not return to baseline. In this animal model, DPOAEs were found to be sensitive measures of cochlear function during transient cochlear ischemic episodes, suggesting the utility of DPOAE monitoring of auditory function during surgery of cerebello-pontine angle tumors.
AB - The aim of this study was to investigate the utility of distortion product otoacoustic emissions (DPOAEs) in intraoperative monitoring (IM) of cochlear ischemic episodes in animals during internal auditory artery (IAA) compression. The IAA was exposed using the posterior fossa approach and then compressed for 3 and 5 min intervals to effect ischemia. DPOAE amplitudes and phases were measured at 4, 8, and 12 kHz geometric mean frequency (GMF). In each monitored ear, laser-Doppler cochlear blood flow (CBF) was measured. All IAA compressions resulted in rapid decrease of DPOAE amplitude and CBF, with simultaneous DPOAE phase increase. DPOAE phase changes were found to increase consistently within several seconds of IAA compression, while corresponding DPOAE amplitudes changed more slowly, with up to 30-40 s delays. Following IAA release, DPOAEs at 12 kHz GMF were characterized by longer delays in returning to baseline than those measured at lower frequencies. In some cases, CBF did not return to baseline. In this animal model, DPOAEs were found to be sensitive measures of cochlear function during transient cochlear ischemic episodes, suggesting the utility of DPOAE monitoring of auditory function during surgery of cerebello-pontine angle tumors.
KW - Cochlear blood flow
KW - Cochlear ischemia
KW - Cochlear reperfusion
KW - Otoacoustic emissions
UR - http://www.scopus.com/inward/record.url?scp=32844457854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32844457854&partnerID=8YFLogxK
U2 - 10.1016/j.heares.2005.05.019
DO - 10.1016/j.heares.2005.05.019
M3 - Article
C2 - 16403609
AN - SCOPUS:32844457854
VL - 212
SP - 117
EP - 127
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -