A Mini Review of Clinical and Research Applications of the Retinal Function Imager

Liang Wang, Hong Jiang, Amiram Grinvald, Chaitra Jayadev, Jianhua Wang

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Purpose: To review the clinical applications and diagnostic value of the retinal function imager (RFI), briefly compare RFI to other optical imaging devices, and to describe recent developments. Methods: The search words “Retinal Functional Imager,” “optical imaging,” “retina angiography,” “avascular zone,” “foveal avascular zone,” and other closely related terms were used in PubMed to review current literature involving the RFI. Results: The functions of the RFI were utilized in over 44 microvascular studies, which reported that the microvasculature may alter in velocity, morphology, and oximetry when affected by a number of ocular, neurological, or systemic diseases. Recently developed automatic algorithms for noninvasive angiography of large retinal regions, segmenting vessels, measuring blood flow, blood velocity, vessel diameter, and oximetry may enhance the clinical applications of the RFI. Conclusion: The RFI has been used to characterize the retinal microvasculature under various conditions of all prevalent retinal diseases in addition to some central nerve system (CNS) and systemic diseases. Applying the RFI in research and clinical settings should help earlier diagnosis, support disease prevention, and improve treatment management.

Original languageEnglish (US)
Pages (from-to)273-288
Number of pages16
JournalCurrent Eye Research
Issue number3
StatePublished - Mar 4 2018


  • DR AMD
  • Retina
  • angiography
  • blood flow
  • blood velocity
  • capillaries
  • conjunctiva
  • glaucoma
  • metabolic syndrome
  • multiple sclerosis
  • neurological diseases
  • optical imaging
  • oximetry
  • vein occlusion

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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