A method for in vivo high resolution MRI of rat spinal cord injury

John C. Ford; David B. Hackney; Peter M. Joseph; Megan Phelan; David C. Alsop; Stacy L. Tabor; Christopher M. Hand; Ronald S. Markowitz; Perry Black

doi:10.1002/mrm.1910310216

A method for in vivo high resolution MRI of rat spinal cord injury

John C. Ford, David B. Hackney, Peter M. Joseph, Megan Phelan, David C. Alsop, Stacy L. Tabor, Christopher M. Hand, Ronald S. Markowitz, Perry Black

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We have developed an implanted radiofrequency coil to obtain high resolution in vivo MR images at 1.9 Tesla of rat spinal cords that have been injured using a standardized weight drop technique. The signal‐to‐noise ratio and motion artifact suppression of these images is superior to that achieved in earlier attempts at this field strength using an external surface coil. The high quality and spatial resolution provided by this technique afford the possibility for longitudinal studies of experimental spinal cord injury before and after treatment, as well as detailed correlation of in vivo MRI contrast, histopathological findings, and functional deficit, in a controlled setting.

Original language	English (US)
Pages (from-to)	218-223
Number of pages	6
Journal	Magnetic Resonance in Medicine
Volume	31
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910310216
State	Published - Feb 1994
Externally published	Yes

Keywords

high resolution MRI
radiofrequency coils
spinal cord injury

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.1910310216

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title = "A method for in vivo high resolution MRI of rat spinal cord injury",

abstract = "We have developed an implanted radiofrequency coil to obtain high resolution in vivo MR images at 1.9 Tesla of rat spinal cords that have been injured using a standardized weight drop technique. The signal‐to‐noise ratio and motion artifact suppression of these images is superior to that achieved in earlier attempts at this field strength using an external surface coil. The high quality and spatial resolution provided by this technique afford the possibility for longitudinal studies of experimental spinal cord injury before and after treatment, as well as detailed correlation of in vivo MRI contrast, histopathological findings, and functional deficit, in a controlled setting.",

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AU - Alsop, David C.

AU - Tabor, Stacy L.

AU - Hand, Christopher M.

AU - Markowitz, Ronald S.

AU - Black, Perry

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AB - We have developed an implanted radiofrequency coil to obtain high resolution in vivo MR images at 1.9 Tesla of rat spinal cords that have been injured using a standardized weight drop technique. The signal‐to‐noise ratio and motion artifact suppression of these images is superior to that achieved in earlier attempts at this field strength using an external surface coil. The high quality and spatial resolution provided by this technique afford the possibility for longitudinal studies of experimental spinal cord injury before and after treatment, as well as detailed correlation of in vivo MRI contrast, histopathological findings, and functional deficit, in a controlled setting.

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A method for in vivo high resolution MRI of rat spinal cord injury

Abstract

Keywords

ASJC Scopus subject areas

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