A mammalian protein with specific demethylase activity for mCpG DNA

Sanjoy K. Bhattacharya, Shyam Ramchandani, Nadia Cervoni, Moshe Szyf

Research output: Contribution to journalArticlepeer-review

529 Scopus citations


DNA-methylation patterns are Important for regulating genome functions, and are determined by the enzymatic processes of methylation and demethylation. The demethylating enzyme has now been identified: a mammalian complementary DNA encodes a methyl-CpG-binding domain, bears a demethylase activity that transforms methylated cytosine bases to cytosine, and demethylates a plasmid when the cDNA is translated or transiently transfected into human embryonal kidney cells in vitro. The discovery of this DNA demethylase should provide a basis for the molecular and developmental analysis of the role of DNA methylation and demethylation.

Original languageEnglish (US)
Pages (from-to)579-583
Number of pages5
Issue number6720
StatePublished - Feb 18 1999
Externally publishedYes

ASJC Scopus subject areas

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