A magnetic resonance imaging study of putamen nuclei in major depression

Mustafa M. Husain, William M. McDonald, P. Murali Doraiswamy, Gary S. Figiel, Chul Na, P. Rodrigo Escalona, Orest B. Boyko, Charles B. Nemeroff, K. Ranga R. Krishnan

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depressive mood, and psychosis. Using high resolution, axial T2 intermediate magnetic resonance images, and a systematic sampling stereologic method, we assessed putamen nuclei volumes in 41 patients with major depression (DSM-III) and 44 healthy volunteer controls of similar age. Depressed patients had significantly smaller putamen nuclei compared with controls. Age was negatively correlated with putamen size in both groups. These results are the first demonstration of diminished putamen volumes in depression and further support a role for basal ganglia structures in the etiopathogenesis of depression.

Original languageEnglish (US)
Pages (from-to)95-99
Number of pages5
JournalPsychiatry Research: Neuroimaging
Volume40
Issue number2
DOIs
StatePublished - Oct 1991
Externally publishedYes

Keywords

  • basal ganglia
  • limbic system
  • Magnetic resonance imaging
  • major depression
  • putamen nuclei

ASJC Scopus subject areas

  • Psychology(all)
  • Biological Psychiatry
  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'A magnetic resonance imaging study of putamen nuclei in major depression'. Together they form a unique fingerprint.

  • Cite this

    Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Na, C., Escalona, P. R., Boyko, O. B., Nemeroff, C. B., & Krishnan, K. R. R. (1991). A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Research: Neuroimaging, 40(2), 95-99. https://doi.org/10.1016/0925-4927(91)90001-7