A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death

Lin Wang, Arin Bhattacharjee, Zhuang Zuo, Fuquan Hu, Richard E. Honkanen, Per Olof Berggren, Ming Li

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Insulin-dependent diabetes mellitus is characterized by the selective destruction of pancreatic β-cells. Chronic treatment with cytokines induced a low voltage-activated (LVA) Ca2+ current in mouse β-cells. The concomitant increase in the basal cytoplasmic free Ca2+ concentration ([Ca2+](i)) was associated with DNA fragmentation and cell death. Antagonists of LVA Ca2+ channels prevented this elevation of basal [Ca2+](i) and DNA fragmentation and reduced the percentage of cell death. Exposure to cytokines did not affect the profile of Ca2+ currents or basal [Ca2+ ](i) in glucagon-secreting α-cells. An increased Ca2+ signal through LVA Ca2+ channels may thus be a key feature in cytokine-induced β- cell destruction.

Original languageEnglish (US)
Pages (from-to)1200-1204
Number of pages5
JournalEndocrinology
Volume140
Issue number3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology

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