A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death

Lin Wang, Arin Bhattacharjee, Zhuang Zuo, Fuquan Hu, Richard E. Honkanen, Per Olof Berggren, Ming Li

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Insulin-dependent diabetes mellitus is characterized by the selective destruction of pancreatic β-cells. Chronic treatment with cytokines induced a low voltage-activated (LVA) Ca2+ current in mouse β-cells. The concomitant increase in the basal cytoplasmic free Ca2+ concentration ([Ca2+](i)) was associated with DNA fragmentation and cell death. Antagonists of LVA Ca2+ channels prevented this elevation of basal [Ca2+](i) and DNA fragmentation and reduced the percentage of cell death. Exposure to cytokines did not affect the profile of Ca2+ currents or basal [Ca2+ ](i) in glucagon-secreting α-cells. An increased Ca2+ signal through LVA Ca2+ channels may thus be a key feature in cytokine-induced β- cell destruction.

Original languageEnglish
Pages (from-to)1200-1204
Number of pages5
JournalEndocrinology
Volume140
Issue number3
StatePublished - Jan 1 1999
Externally publishedYes

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Cell Death
DNA Fragmentation
Cytokines
Glucagon-Secreting Cells
Type 1 Diabetes Mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Wang, L., Bhattacharjee, A., Zuo, Z., Hu, F., Honkanen, R. E., Berggren, P. O., & Li, M. (1999). A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death. Endocrinology, 140(3), 1200-1204.

A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death. / Wang, Lin; Bhattacharjee, Arin; Zuo, Zhuang; Hu, Fuquan; Honkanen, Richard E.; Berggren, Per Olof; Li, Ming.

In: Endocrinology, Vol. 140, No. 3, 01.01.1999, p. 1200-1204.

Research output: Contribution to journalArticle

Wang, L, Bhattacharjee, A, Zuo, Z, Hu, F, Honkanen, RE, Berggren, PO & Li, M 1999, 'A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death', Endocrinology, vol. 140, no. 3, pp. 1200-1204.
Wang L, Bhattacharjee A, Zuo Z, Hu F, Honkanen RE, Berggren PO et al. A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death. Endocrinology. 1999 Jan 1;140(3):1200-1204.
Wang, Lin ; Bhattacharjee, Arin ; Zuo, Zhuang ; Hu, Fuquan ; Honkanen, Richard E. ; Berggren, Per Olof ; Li, Ming. / A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic β-cell death. In: Endocrinology. 1999 ; Vol. 140, No. 3. pp. 1200-1204.
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