A linkage disequilibrium map of the 1-Mb 15q12 GABAA receptor subunit cluster and association to autism

Jacob L. McCauley, Lana M. Olson, Ryan Delahanty, Taneem Amin, Erika L. Nurmi, Edward L. Organ, Michelle M. Jacobs, Susan E. Folstein, Jonathan L. Haines, James S. Sutcliffe

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Autism is a complex genetic neuropsychiatric condition characterized by deficits in social interaction and language and patterns of repetitive or stereotyped behaviors and restricted interests. Chromosome 15q11.2-q13 is a candidate region for autism susceptibility based on observations of chromosomal duplications in a small percentage of affected individuals and findings of linkage and association. We performed linkage disequilibrium (LD) mapping across a 1-Mb interval containing a cluster of GABAA receptor subunit genes (GABRB3, GABRA5, and GABRG3) which are good positional and functional candidates. Intermarker LD was measured for 59 single nucleotide polymorphism (SNP) markers spanning this region, corresponding to an average marker spacing of 17.7 kb-1. We identified haplotype blocks, and characterized these blocks for common (>5%) haplotypes present in the study population. At this marker resolution, haplotype blocks comprise <50% of the DNA in this region, consistent with a high local recombination rate. Identification of haplotype tag SNPs reduces the overall number of markers necessary to detect all common alleles by only 12%. Individual SNPs and multi-SNP haplotypes were examined for evidence of allelic association to autism, using a dataset of 123 multiplex autism families. Six markers individually, across GABRB3 and GABRA5, and several haplotypes inclusive of those markers, demonstrated nominally significant association. These results are positively correlated with the position of observed linkage. These studies support the existence of one or more autism risk alleles in the GABAA receptor subunit cluster on 15q12 and have implications for analysis of LD and association in regions with high local recombination.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume131 B
Issue number1
DOIs
StatePublished - Nov 15 2004

Keywords

  • Association
  • Autism
  • Haplotype
  • Linkage disequilibrium

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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    McCauley, J. L., Olson, L. M., Delahanty, R., Amin, T., Nurmi, E. L., Organ, E. L., Jacobs, M. M., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2004). A linkage disequilibrium map of the 1-Mb 15q12 GABAA receptor subunit cluster and association to autism. American Journal of Medical Genetics - Neuropsychiatric Genetics, 131 B(1), 51-59. https://doi.org/10.1002/ajmg.b.30038