A-Kinase anchoring proteins as the basis for camp signaling

K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Abstract

Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacialoral control of cAMP signaling.

Original languageEnglish (US)
Title of host publicationProtein-Protein Interactions as New Drug Targets
EditorsEnno Klussmann, John Scott
Pages3-14
Number of pages12
DOIs
StatePublished - Dec 1 2008

Publication series

NameHandbook of Experimental Pharmacology
Volume186
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Dodge-Kafka, K. L., Bauman, A., & Kapiloff, M. S. (2008). A-Kinase anchoring proteins as the basis for camp signaling. In E. Klussmann, & J. Scott (Eds.), Protein-Protein Interactions as New Drug Targets (pp. 3-14). (Handbook of Experimental Pharmacology; Vol. 186). https://doi.org/10.1007/978-3-540-72843-6-1