A-Kinase anchoring proteins as the basis for camp signaling

K. L. Dodge-Kafka, A. Bauman, Michael S Kapiloff

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

Common challenges to any cell are the processing of the extracellular stimuli it receives into intracellular signaling cascades that initiate a multitude of diverse biological functions. However, many of these stimuli act via a common signaling pathway, suggesting the cell must somehow discriminate between different stimuli and respond accordingly. Subcellular targeting through the association with adaptor and scaffolding proteins has emerged as a key mechanism by which cells maintain signaling specificity. Compartmentation of cAMP signaling is maintained by the clustering of cAMP signaling enzymes in discrete units by the scaffolding protein A-kinase anchoring proteins (AKAP). In doing so, AKAPs provide the molecular architecture for the cAMP micordomains that underlie the spacialoral control of cAMP signaling.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
Pages3-14
Number of pages12
Volume186
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume186
ISSN (Print)01712004
ISSN (Electronic)18650325

Fingerprint

Protein Kinases
Phosphotransferases
Proteins
Staphylococcal Protein A
Cluster Analysis
Cell signaling
Enzymes
Processing

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry
  • Medicine(all)

Cite this

Dodge-Kafka, K. L., Bauman, A., & Kapiloff, M. S. (2008). A-Kinase anchoring proteins as the basis for camp signaling. In Handbook of Experimental Pharmacology (Vol. 186, pp. 3-14). (Handbook of Experimental Pharmacology; Vol. 186). https://doi.org/10.1007/978-3-540-72843-6-1

A-Kinase anchoring proteins as the basis for camp signaling. / Dodge-Kafka, K. L.; Bauman, A.; Kapiloff, Michael S.

Handbook of Experimental Pharmacology. Vol. 186 2008. p. 3-14 (Handbook of Experimental Pharmacology; Vol. 186).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dodge-Kafka, KL, Bauman, A & Kapiloff, MS 2008, A-Kinase anchoring proteins as the basis for camp signaling. in Handbook of Experimental Pharmacology. vol. 186, Handbook of Experimental Pharmacology, vol. 186, pp. 3-14. https://doi.org/10.1007/978-3-540-72843-6-1
Dodge-Kafka KL, Bauman A, Kapiloff MS. A-Kinase anchoring proteins as the basis for camp signaling. In Handbook of Experimental Pharmacology. Vol. 186. 2008. p. 3-14. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-540-72843-6-1
Dodge-Kafka, K. L. ; Bauman, A. ; Kapiloff, Michael S. / A-Kinase anchoring proteins as the basis for camp signaling. Handbook of Experimental Pharmacology. Vol. 186 2008. pp. 3-14 (Handbook of Experimental Pharmacology).
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