We hypothesize that a novel signaling loop of high-level activation in tumor cells, which is triggered by heparanase overexpression and growth factors and plays a crucial role in tumor progression. It is believed that clarification on the malignant loop will provide us with new ideas about revealing pathogenesis of tumors and define a range of novel and exciting therapeutic approaches.
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Agricultural and Biological Sciences (miscellaneous)