A hypothetical signaling loop with tumor progression triggered by heparanase overexpression and growth factors

Qi Luan, Jing Sun, Chun Ying Li, Jie Li, Ya Jie Lv, Cheng Xin Li, Gang Wang, Tian Wen Gao

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We hypothesize that a novel signaling loop of high-level activation in tumor cells, which is triggered by heparanase overexpression and growth factors and plays a crucial role in tumor progression. It is believed that clarification on the malignant loop will provide us with new ideas about revealing pathogenesis of tumors and define a range of novel and exciting therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)118-120
Number of pages3
JournalBioscience Hypotheses
Volume1
Issue number2
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)

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