A hypothetical signaling loop with tumor progression triggered by heparanase overexpression and growth factors

Qi Luan, Jing Sun, Chun Ying Li, Jie Li, Ya Jie Lv, Cheng Xin Li, Gang Wang, Tian Wen Gao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We hypothesize that a novel signaling loop of high-level activation in tumor cells, which is triggered by heparanase overexpression and growth factors and plays a crucial role in tumor progression. It is believed that clarification on the malignant loop will provide us with new ideas about revealing pathogenesis of tumors and define a range of novel and exciting therapeutic approaches.

Original languageEnglish
Pages (from-to)118-120
Number of pages3
JournalBioscience Hypotheses
Volume1
Issue number2
DOIs
StatePublished - Aug 5 2008

Fingerprint

growth factors
Tumors
Intercellular Signaling Peptides and Proteins
neoplasms
Neoplasms
pathogenesis
therapeutics
Chemical activation
Cells
heparanase
Therapeutics
neoplasm cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)

Cite this

A hypothetical signaling loop with tumor progression triggered by heparanase overexpression and growth factors. / Luan, Qi; Sun, Jing; Li, Chun Ying; Li, Jie; Lv, Ya Jie; Li, Cheng Xin; Wang, Gang; Gao, Tian Wen.

In: Bioscience Hypotheses, Vol. 1, No. 2, 05.08.2008, p. 118-120.

Research output: Contribution to journalArticle

Luan, Qi ; Sun, Jing ; Li, Chun Ying ; Li, Jie ; Lv, Ya Jie ; Li, Cheng Xin ; Wang, Gang ; Gao, Tian Wen. / A hypothetical signaling loop with tumor progression triggered by heparanase overexpression and growth factors. In: Bioscience Hypotheses. 2008 ; Vol. 1, No. 2. pp. 118-120.
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