A hydatidiform mole in a postmenopausal woman: A case report and review of the literature

Research output: Contribution to journalArticle

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Abstract

Gestational trophoblastic disease occurs in less than 1 per 1200 pregnancies in the United States. The spectrum of this disease ranges from benign hydatidiform mole to trophoblastic malignancy (placental-site trophoblastic tumor and choriocarcinoma). Benign gestational trophoblastic disease generally occurs in women of reproductive age and is extremely rare in postmenopausal women. To our knowledge, our case represents only the third description in the world literature of a benign complete hydatidiform mole in a woman with a history of amenorrhea greater than 1 year. We describe the case of a 61-year-old post-menopausal woman who underwent an emergent total abdominal hysterectomy due to uncontrollable vaginal bleeding associated with an increased serum β-human chorionic gonadotropin level. The resected uterus contained an endometrial, cystic, grapelike tumor. Microscopic examination demonstrated hydropic degenerated villi with a circumferential trophoblastic cell proliferation and moderate atypia, consistent with a complete hydatidiform mole. The morphologic and immunophenotypic characteristics are presented, as well as the results of a literature review.

Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume128
Issue number9
StatePublished - Sep 1 2004

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Hydatidiform Mole
Gestational Trophoblastic Disease
Placental Site Trophoblastic Tumor
Choriocarcinoma
Uterine Hemorrhage
Amenorrhea
Chorionic Gonadotropin
Hysterectomy
Uterus
Edema
Neoplasms
Cell Proliferation
Pregnancy
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

A hydatidiform mole in a postmenopausal woman : A case report and review of the literature. / Garcia-Buitrago, Monica; Romaguera, Rita L.; Gomez-Fernandez, Carmen.

In: Archives of Pathology and Laboratory Medicine, Vol. 128, No. 9, 01.09.2004, p. 1039-1042.

Research output: Contribution to journalArticle

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