A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling

Jing Zhou, Boonchoy Soontornworajit, Jacob Martin, Bruce A. Sullenger, Eli Gilboa, Yong Wang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Antibodies are natural nanomaterials and have been widely used for targeted cell labeling. However, the applications of antibodies are often limited by their large size and instability. The purpose of this study is to develop a new type of multifunctional nanomaterial that is comprised of a nucleic acid aptamer and a dendrimer, both of which are stable. This nanomaterial is ≈8 nm in size. Moreover, it could not only carry multiple signal molecules, but also bind to target cancer cells with high affinity and specificity. This sub-10nm multifunctional nanomaterial is expected to be useful in basic biomedical research and clinical medicine. (Figure Presented)

Original languageEnglish
Pages (from-to)831-835
Number of pages5
JournalMacromolecular Bioscience
Volume9
Issue number9
DOIs
StatePublished - Sep 9 2009

Fingerprint

Nucleotide Aptamers
Dendrimers
Nanostructures
Nanostructured materials
Labeling
DNA
Antibodies
Clinical Medicine
Nucleic acids
Nucleic Acids
Medicine
Biomedical Research
Cells
Molecules
Neoplasms

Keywords

  • Aptamers
  • Cell labelling
  • Dendrimers
  • Molecular recognition
  • Nanomaterials

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Zhou, J., Soontornworajit, B., Martin, J., Sullenger, B. A., Gilboa, E., & Wang, Y. (2009). A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. Macromolecular Bioscience, 9(9), 831-835. https://doi.org/10.1002/mabi.200900046

A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. / Zhou, Jing; Soontornworajit, Boonchoy; Martin, Jacob; Sullenger, Bruce A.; Gilboa, Eli; Wang, Yong.

In: Macromolecular Bioscience, Vol. 9, No. 9, 09.09.2009, p. 831-835.

Research output: Contribution to journalArticle

Zhou, J, Soontornworajit, B, Martin, J, Sullenger, BA, Gilboa, E & Wang, Y 2009, 'A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling', Macromolecular Bioscience, vol. 9, no. 9, pp. 831-835. https://doi.org/10.1002/mabi.200900046
Zhou, Jing ; Soontornworajit, Boonchoy ; Martin, Jacob ; Sullenger, Bruce A. ; Gilboa, Eli ; Wang, Yong. / A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling. In: Macromolecular Bioscience. 2009 ; Vol. 9, No. 9. pp. 831-835.
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