A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Edio Maldonado, Ramin Shiekhattar, Michael Sheldon, Helen Cho, Ronny Drapkin, Paula Rickert, Emma Leest, Carl W. Anderson, Stuart Linn, Danny Reinberg

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalNature
Volume381
Issue number6577
DOIs
StatePublished - May 2 1996
Externally publishedYes

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RNA Polymerase II
DNA Repair
Proteins
Transcriptional Activation
Transcription Factors
Yeasts

ASJC Scopus subject areas

  • General

Cite this

Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H., Drapkin, R., Rickert, P., ... Reinberg, D. (1996). A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature, 381(6577), 86-89. https://doi.org/10.1038/381086a0

A human RNA polymerase II complex associated with SRB and DNA-repair proteins. / Maldonado, Edio; Shiekhattar, Ramin; Sheldon, Michael; Cho, Helen; Drapkin, Ronny; Rickert, Paula; Leest, Emma; Anderson, Carl W.; Linn, Stuart; Reinberg, Danny.

In: Nature, Vol. 381, No. 6577, 02.05.1996, p. 86-89.

Research output: Contribution to journalArticle

Maldonado, E, Shiekhattar, R, Sheldon, M, Cho, H, Drapkin, R, Rickert, P, Leest, E, Anderson, CW, Linn, S & Reinberg, D 1996, 'A human RNA polymerase II complex associated with SRB and DNA-repair proteins', Nature, vol. 381, no. 6577, pp. 86-89. https://doi.org/10.1038/381086a0
Maldonado E, Shiekhattar R, Sheldon M, Cho H, Drapkin R, Rickert P et al. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature. 1996 May 2;381(6577):86-89. https://doi.org/10.1038/381086a0
Maldonado, Edio ; Shiekhattar, Ramin ; Sheldon, Michael ; Cho, Helen ; Drapkin, Ronny ; Rickert, Paula ; Leest, Emma ; Anderson, Carl W. ; Linn, Stuart ; Reinberg, Danny. / A human RNA polymerase II complex associated with SRB and DNA-repair proteins. In: Nature. 1996 ; Vol. 381, No. 6577. pp. 86-89.
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