A high frequency of PALB2 mutations in Jamaican patients with breast cancer

Jordan Lerner-Ellis, Talia Donenberg, Humayun Ahmed, Sophia George, Gilian Wharfe, Sheray Chin, Dwight Lowe, Robert Royer, Shiyu Zhang, Steven Narod, Judith Hurley, Mohammad R. Akbari

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Jamaica is an island nation with one of the highest breast cancer incidence rates in the Caribbean (40/100,000 per year). The contribution of cancer susceptibility gene mutations to the burden of breast cancer in Jamaica has not yet been explored. We sought to determine the prevalence of germline mutations in BRCA1, BRCA2, and PALB2 in 179 unselected Jamaican women with breast cancer. Methods: We sequenced the entire coding regions of BRCA1, BRCA2, and PALB2 for all the study subjects. Results: Overall, 8 of 179 patients (4.5%) had a mutation in one of the three genes: one in BRCA1, two in BRCA2, and five in PALB2. Conclusions: These data suggest that in addition to BRCA1 and BRCA2, PALB2 should be included in genetic testing for breast cancer patients in Jamaica.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalBreast Cancer Research and Treatment
Volume162
Issue number3
DOIs
StatePublished - Apr 1 2017

Fingerprint

Mutation Rate
Jamaica
Breast Neoplasms
Mutation
Germ-Line Mutation
Neoplasm Genes
Genetic Testing
Islands
Incidence
Genes

Keywords

  • BRCA1
  • BRCA2
  • Breast cancer
  • Hereditary
  • Jamaica
  • PALB2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lerner-Ellis, J., Donenberg, T., Ahmed, H., George, S., Wharfe, G., Chin, S., ... Akbari, M. R. (2017). A high frequency of PALB2 mutations in Jamaican patients with breast cancer. Breast Cancer Research and Treatment, 162(3), 591-596. https://doi.org/10.1007/s10549-017-4148-1

A high frequency of PALB2 mutations in Jamaican patients with breast cancer. / Lerner-Ellis, Jordan; Donenberg, Talia; Ahmed, Humayun; George, Sophia; Wharfe, Gilian; Chin, Sheray; Lowe, Dwight; Royer, Robert; Zhang, Shiyu; Narod, Steven; Hurley, Judith; Akbari, Mohammad R.

In: Breast Cancer Research and Treatment, Vol. 162, No. 3, 01.04.2017, p. 591-596.

Research output: Contribution to journalArticle

Lerner-Ellis, J, Donenberg, T, Ahmed, H, George, S, Wharfe, G, Chin, S, Lowe, D, Royer, R, Zhang, S, Narod, S, Hurley, J & Akbari, MR 2017, 'A high frequency of PALB2 mutations in Jamaican patients with breast cancer', Breast Cancer Research and Treatment, vol. 162, no. 3, pp. 591-596. https://doi.org/10.1007/s10549-017-4148-1
Lerner-Ellis, Jordan ; Donenberg, Talia ; Ahmed, Humayun ; George, Sophia ; Wharfe, Gilian ; Chin, Sheray ; Lowe, Dwight ; Royer, Robert ; Zhang, Shiyu ; Narod, Steven ; Hurley, Judith ; Akbari, Mohammad R. / A high frequency of PALB2 mutations in Jamaican patients with breast cancer. In: Breast Cancer Research and Treatment. 2017 ; Vol. 162, No. 3. pp. 591-596.
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AU - Lerner-Ellis, Jordan

AU - Donenberg, Talia

AU - Ahmed, Humayun

AU - George, Sophia

AU - Wharfe, Gilian

AU - Chin, Sheray

AU - Lowe, Dwight

AU - Royer, Robert

AU - Zhang, Shiyu

AU - Narod, Steven

AU - Hurley, Judith

AU - Akbari, Mohammad R.

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AB - Purpose: Jamaica is an island nation with one of the highest breast cancer incidence rates in the Caribbean (40/100,000 per year). The contribution of cancer susceptibility gene mutations to the burden of breast cancer in Jamaica has not yet been explored. We sought to determine the prevalence of germline mutations in BRCA1, BRCA2, and PALB2 in 179 unselected Jamaican women with breast cancer. Methods: We sequenced the entire coding regions of BRCA1, BRCA2, and PALB2 for all the study subjects. Results: Overall, 8 of 179 patients (4.5%) had a mutation in one of the three genes: one in BRCA1, two in BRCA2, and five in PALB2. Conclusions: These data suggest that in addition to BRCA1 and BRCA2, PALB2 should be included in genetic testing for breast cancer patients in Jamaica.

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