A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus

Ronald C. Desrosiers, Vito G. Sasseville, Susan C. Czajak, Xiaoming Zhang, Keith G. Mansfield, Amitinder Kaur, R. Paul Johnson, Andrew A. Lackner, Jae U. Jung

Research output: Contribution to journalArticle

213 Scopus citations

Abstract

A herpesvirus that is related to but distinct from the Kaposi's sarcoma- associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.

Original languageEnglish (US)
Pages (from-to)9764-9769
Number of pages6
JournalJournal of virology
Volume71
Issue number12
DOIs
StatePublished - Dec 1997

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Desrosiers, R. C., Sasseville, V. G., Czajak, S. C., Zhang, X., Mansfield, K. G., Kaur, A., Johnson, R. P., Lackner, A. A., & Jung, J. U. (1997). A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus. Journal of virology, 71(12), 9764-9769. https://doi.org/10.1128/jvi.71.12.9764-9769.1997