A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus

Ronald Charles Desrosiers, Vito G. Sasseville, Susan C. Czajak, Xiaoming Zhang, Keith G. Mansfield, Amitinder Kaur, R. Paul Johnson, Andrew A. Lackner, Jae U. Jung

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

A herpesvirus that is related to but distinct from the Kaposi's sarcoma- associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.

Original languageEnglish (US)
Pages (from-to)9764-9769
Number of pages6
JournalJournal of Virology
Volume71
Issue number12
StatePublished - Dec 1997
Externally publishedYes

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Human herpesvirus 8
Human Herpesvirus 8
Herpesviridae
Macaca mulatta
Rhadinovirus
Reading Frames
DNA-directed DNA polymerase
antibody detection
DNA-Directed DNA Polymerase
virion
interleukin-6
Virion
fibroblasts
glycoproteins
Interleukin-6
Glycoproteins
Fibroblasts
Viruses
viruses
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Desrosiers, R. C., Sasseville, V. G., Czajak, S. C., Zhang, X., Mansfield, K. G., Kaur, A., ... Jung, J. U. (1997). A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus. Journal of Virology, 71(12), 9764-9769.

A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus. / Desrosiers, Ronald Charles; Sasseville, Vito G.; Czajak, Susan C.; Zhang, Xiaoming; Mansfield, Keith G.; Kaur, Amitinder; Johnson, R. Paul; Lackner, Andrew A.; Jung, Jae U.

In: Journal of Virology, Vol. 71, No. 12, 12.1997, p. 9764-9769.

Research output: Contribution to journalArticle

Desrosiers, RC, Sasseville, VG, Czajak, SC, Zhang, X, Mansfield, KG, Kaur, A, Johnson, RP, Lackner, AA & Jung, JU 1997, 'A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus', Journal of Virology, vol. 71, no. 12, pp. 9764-9769.
Desrosiers RC, Sasseville VG, Czajak SC, Zhang X, Mansfield KG, Kaur A et al. A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus. Journal of Virology. 1997 Dec;71(12):9764-9769.
Desrosiers, Ronald Charles ; Sasseville, Vito G. ; Czajak, Susan C. ; Zhang, Xiaoming ; Mansfield, Keith G. ; Kaur, Amitinder ; Johnson, R. Paul ; Lackner, Andrew A. ; Jung, Jae U. / A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma- associated herpesvirus. In: Journal of Virology. 1997 ; Vol. 71, No. 12. pp. 9764-9769.
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