A helicase is born

Research output: Contribution to journalArticle

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Abstract

One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.

Original languageEnglish
Pages (from-to)200-201
Number of pages2
JournalNature Genetics
Volume28
Issue number3
DOIs
StatePublished - Jul 20 2001

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Chronic Progressive External Ophthalmoplegia
Bacteriophage T7
Mitochondrial DNA
Genes
Nucleotides
Mutation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

A helicase is born. / Moraes, Carlos T.

In: Nature Genetics, Vol. 28, No. 3, 20.07.2001, p. 200-201.

Research output: Contribution to journalArticle

Moraes, Carlos T. / A helicase is born. In: Nature Genetics. 2001 ; Vol. 28, No. 3. pp. 200-201.
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