A helicase is born

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations


One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.

Original languageEnglish (US)
Pages (from-to)200-201
Number of pages2
JournalNature genetics
Issue number3
StatePublished - Jul 20 2001

ASJC Scopus subject areas

  • Genetics


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