Abstract
One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 200-201 |
| Number of pages | 2 |
| Journal | Nature genetics |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 20 2001 |
ASJC Scopus subject areas
- Genetics
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Cite this
Moraes, C. T. (2001). A helicase is born. Nature genetics, 28(3), 200-201. https://doi.org/10.1038/90020