A helicase is born

C. T. Moraes

doi:10.1038/90020

A helicase is born

C. T. Moraes

Neurology

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.

Original language	English (US)
Pages (from-to)	200-201
Number of pages	2
Journal	Nature genetics
Volume	28
Issue number	3
DOIs	https://doi.org/10.1038/90020
State	Published - Jul 20 2001

ASJC Scopus subject areas

Genetics

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10.1038/90020

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title = "A helicase is born",

abstract = "One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.",

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AB - One of three loci previously associated with autosomal dominant progressive external ophthalmoplegia (adPEO) encodes ANT1, a mitochondrial nucleotide transporter. Now, mutations in two other genes are found in people with adPEO. One of these encodes a new helicase, Twinkle, which is related to the product of bacteriophage T7 gene 4, and co-localizes with mitochondrial DNA. The identification of Twinkle adds a new star to the expanding constellation of 'helicase diseases'.

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