Abstract
Nash MS, Mendez AJ. A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia. Objective: To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines. Design: Cross-sectional. Setting: Academic medical center. Participants: Forty-one subjects (mean age ± standard deviation, 34±11y) with motor-complete paraplegia (American Spinal Injury Association grade A or B) at T6-L1 levels for greater than 2 years. Interventions: Not applicable. Main Outcome Measures: Percentages of subjects qualifying for TLI were independently assessed and then compared using National Cholesterol Education Project Adult Treatment Panel (ATP) II (1994) and ATP III (2002) Guidelines. Results: A total of 34.1% of subjects qualified for intervention based on the ATP II Guidelines and 63.4% based on ATP III (χ12 test=4.53; 2-tailed, P=.003). Seventy-six percent (31/41) of study participants had high-density lipoprotein cholesterol levels below the high-risk criterion of 40mg/dL established by ATP III. Almost one third of subjects had hypertension, and 34.1% satisfied criteria for diagnosis of the metabolic syndrome. Conclusions: A high percentage of young, apparently healthy people with chronic paraplegia are at risk for cardiovascular disease and qualify for lipid-lowering TLI. Updated guidelines of the ATP III have increased the urgency for early risk assessment and intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 751-757 |
| Number of pages | 7 |
| Journal | Archives of Physical Medicine and Rehabilitation |
| Volume | 88 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2007 |
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Keywords
- Cardiovascular diseases
- Lipids
- Paraplegia
- Rehabilitation
- Risk
ASJC Scopus subject areas
- Rehabilitation
Cite this
A Guideline-Driven Assessment of Need for Cardiovascular Disease Risk Intervention in Persons With Chronic Paraplegia. / Nash, Mark S; Mendez, Armando J.
In: Archives of Physical Medicine and Rehabilitation, Vol. 88, No. 6, 01.06.2007, p. 751-757.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Guideline-Driven Assessment of Need for Cardiovascular Disease Risk Intervention in Persons With Chronic Paraplegia
AU - Nash, Mark S
AU - Mendez, Armando J
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Nash MS, Mendez AJ. A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia. Objective: To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines. Design: Cross-sectional. Setting: Academic medical center. Participants: Forty-one subjects (mean age ± standard deviation, 34±11y) with motor-complete paraplegia (American Spinal Injury Association grade A or B) at T6-L1 levels for greater than 2 years. Interventions: Not applicable. Main Outcome Measures: Percentages of subjects qualifying for TLI were independently assessed and then compared using National Cholesterol Education Project Adult Treatment Panel (ATP) II (1994) and ATP III (2002) Guidelines. Results: A total of 34.1% of subjects qualified for intervention based on the ATP II Guidelines and 63.4% based on ATP III (χ12 test=4.53; 2-tailed, P=.003). Seventy-six percent (31/41) of study participants had high-density lipoprotein cholesterol levels below the high-risk criterion of 40mg/dL established by ATP III. Almost one third of subjects had hypertension, and 34.1% satisfied criteria for diagnosis of the metabolic syndrome. Conclusions: A high percentage of young, apparently healthy people with chronic paraplegia are at risk for cardiovascular disease and qualify for lipid-lowering TLI. Updated guidelines of the ATP III have increased the urgency for early risk assessment and intervention.
AB - Nash MS, Mendez AJ. A guideline-driven assessment of need for cardiovascular disease risk intervention in persons with chronic paraplegia. Objective: To examine percentages of persons with chronic paraplegia who qualify for lipid-lowering therapeutic lifestyle intervention (TLI) as assessed by authoritative guidelines. Design: Cross-sectional. Setting: Academic medical center. Participants: Forty-one subjects (mean age ± standard deviation, 34±11y) with motor-complete paraplegia (American Spinal Injury Association grade A or B) at T6-L1 levels for greater than 2 years. Interventions: Not applicable. Main Outcome Measures: Percentages of subjects qualifying for TLI were independently assessed and then compared using National Cholesterol Education Project Adult Treatment Panel (ATP) II (1994) and ATP III (2002) Guidelines. Results: A total of 34.1% of subjects qualified for intervention based on the ATP II Guidelines and 63.4% based on ATP III (χ12 test=4.53; 2-tailed, P=.003). Seventy-six percent (31/41) of study participants had high-density lipoprotein cholesterol levels below the high-risk criterion of 40mg/dL established by ATP III. Almost one third of subjects had hypertension, and 34.1% satisfied criteria for diagnosis of the metabolic syndrome. Conclusions: A high percentage of young, apparently healthy people with chronic paraplegia are at risk for cardiovascular disease and qualify for lipid-lowering TLI. Updated guidelines of the ATP III have increased the urgency for early risk assessment and intervention.
KW - Cardiovascular diseases
KW - Lipids
KW - Paraplegia
KW - Rehabilitation
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=34249338076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249338076&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2007.02.031
DO - 10.1016/j.apmr.2007.02.031
M3 - Article
C2 - 17532897
AN - SCOPUS:34249338076
VL - 88
SP - 751
EP - 757
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 6
ER -