A genome screen of 76 families ascertained through two autism probands

Susan Folstein, Jonathan Haines, Rebecca Landa, Joe Piven, Susan Santangelo, Val Sheffield, Veronica Vieland

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Abstract

The CLSA is a formal collaboration among three clinical data collection sites and two laboratories, funded through the NIMH (USA) to carry out a genetic linkage study of autism. The goal is to genotype 150 families in two replicate samples. We are currently completing our first genome screen of 76 families, including 72 sibling pairs and 4 sibling trios and 148 of 153 possible parents. There are several instances of non-Mendelian transmission of markers on chromosome 15q. At the time of the conference, we will present the statistical analysis of the entire genome screen, as well as results from our follow-up of chromosomal regions (e.g., 7, 15, 16) previously reported as providing suggestive evidence of linkage to autism.

Original languageEnglish
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
StatePublished - Nov 6 1998

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Folstein, S., Haines, J., Landa, R., Piven, J., Santangelo, S., Sheffield, V., & Vieland, V. (1998). A genome screen of 76 families ascertained through two autism probands. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6).