A genome scan for serum triglyceride in obese nuclear families

Wei Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, R. Arlen Price

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (Screening Set 11) were genotyped. Quantitative linkage analyses were performed using family regression and variance components methods. We found linkage on the 7q36 region [D7S3058, 174 centimorgan (cM), Logarithm of Odds (LOD) = 2.98] for log-transformed TG. We also found suggestive linkages on chromosomes 20 (D20S164, 101 cM, LOD = 2.34), 13 (111 cM, LOD = 2.00), and 9 (104 cM, LOD = 1.90) as well as some weaker trends for chromosomes 1, 3, 5, 10, 12, and 22. In 58 African American families, LOD scores of 3.66 and 2.62 were observed on two loci on chromosome 16: D16S3369 (64 cM) and MFD466 (100 cM). To verify the 7q36 linkage, we added 60 nuclear families, and the LOD score increased to 3.52 (empirical P< 0.002) on marker D7S3058.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalJournal of Lipid Research
Volume46
Issue number3
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Chromosome 7
  • Hypertriglyceridemia
  • Quantitative trait linkage

ASJC Scopus subject areas

  • Endocrinology

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