A genetic analysis of the validity of the Hypomanic Personality Scale

Sheri L. Johnson, Charles S Carver, Jutta Joormann, Michael Cuccaro

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: Studies of mania risk have increasingly relied on measures of subsyndromal tendencies to experience manic symptoms. The measures of mania risk employed in those studies have been shown to predict manic onset, to show familial associations, and to demonstrate expected correlations with psychosocial variables related to bipolar disorder. However, little work has been conducted to validate such measures against biologically relevant indices, or to consider whether early adversity, which has been shown to be highly elevated among those with bipolar disorder, is related to higher scores on mania risk measures. This study tested whether a well-used, self-report measure of vulnerability to mania is associated with several candidate genes that have previously been linked with bipolar disorder or with early adversity. Interactions of genes with early adversity in the prediction of mania vulnerability were also tested. Methods: Undergraduate students from the University of Miami (Coral Gables, FL, USA) (N = 305) completed the Hypomanic Personality Scale and the Risky Families Scale, and provided blood for genotyping. Results: Findings indicated that the Hypomanic Personality Scale was related to a number of dopamine-relevant polymorphisms and with early adversity. A polymorphism of ANKK1 appeared to specifically increase mania risk in the context of early adversity. Conclusions: These results provide additional support for the validity of the Hypomanic Personality Scale.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalBipolar Disorders
Volume17
Issue number3
DOIs
StatePublished - May 1 2015

Fingerprint

Bipolar Disorder
Personality
Anthozoa
Self Report
Genes
Dopamine
Students

Keywords

  • Bipolar disorder
  • Dopamine
  • Early adversity
  • Genetic polymorphism
  • Mania risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

A genetic analysis of the validity of the Hypomanic Personality Scale. / Johnson, Sheri L.; Carver, Charles S; Joormann, Jutta; Cuccaro, Michael.

In: Bipolar Disorders, Vol. 17, No. 3, 01.05.2015, p. 331-339.

Research output: Contribution to journalArticle

@article{7db1401b0a6743379fe396d784e3447e,
title = "A genetic analysis of the validity of the Hypomanic Personality Scale",
abstract = "Objectives: Studies of mania risk have increasingly relied on measures of subsyndromal tendencies to experience manic symptoms. The measures of mania risk employed in those studies have been shown to predict manic onset, to show familial associations, and to demonstrate expected correlations with psychosocial variables related to bipolar disorder. However, little work has been conducted to validate such measures against biologically relevant indices, or to consider whether early adversity, which has been shown to be highly elevated among those with bipolar disorder, is related to higher scores on mania risk measures. This study tested whether a well-used, self-report measure of vulnerability to mania is associated with several candidate genes that have previously been linked with bipolar disorder or with early adversity. Interactions of genes with early adversity in the prediction of mania vulnerability were also tested. Methods: Undergraduate students from the University of Miami (Coral Gables, FL, USA) (N = 305) completed the Hypomanic Personality Scale and the Risky Families Scale, and provided blood for genotyping. Results: Findings indicated that the Hypomanic Personality Scale was related to a number of dopamine-relevant polymorphisms and with early adversity. A polymorphism of ANKK1 appeared to specifically increase mania risk in the context of early adversity. Conclusions: These results provide additional support for the validity of the Hypomanic Personality Scale.",
keywords = "Bipolar disorder, Dopamine, Early adversity, Genetic polymorphism, Mania risk",
author = "Johnson, {Sheri L.} and Carver, {Charles S} and Jutta Joormann and Michael Cuccaro",
year = "2015",
month = "5",
day = "1",
doi = "10.1111/bdi.12251",
language = "English (US)",
volume = "17",
pages = "331--339",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "3",

}

TY - JOUR

T1 - A genetic analysis of the validity of the Hypomanic Personality Scale

AU - Johnson, Sheri L.

AU - Carver, Charles S

AU - Joormann, Jutta

AU - Cuccaro, Michael

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objectives: Studies of mania risk have increasingly relied on measures of subsyndromal tendencies to experience manic symptoms. The measures of mania risk employed in those studies have been shown to predict manic onset, to show familial associations, and to demonstrate expected correlations with psychosocial variables related to bipolar disorder. However, little work has been conducted to validate such measures against biologically relevant indices, or to consider whether early adversity, which has been shown to be highly elevated among those with bipolar disorder, is related to higher scores on mania risk measures. This study tested whether a well-used, self-report measure of vulnerability to mania is associated with several candidate genes that have previously been linked with bipolar disorder or with early adversity. Interactions of genes with early adversity in the prediction of mania vulnerability were also tested. Methods: Undergraduate students from the University of Miami (Coral Gables, FL, USA) (N = 305) completed the Hypomanic Personality Scale and the Risky Families Scale, and provided blood for genotyping. Results: Findings indicated that the Hypomanic Personality Scale was related to a number of dopamine-relevant polymorphisms and with early adversity. A polymorphism of ANKK1 appeared to specifically increase mania risk in the context of early adversity. Conclusions: These results provide additional support for the validity of the Hypomanic Personality Scale.

AB - Objectives: Studies of mania risk have increasingly relied on measures of subsyndromal tendencies to experience manic symptoms. The measures of mania risk employed in those studies have been shown to predict manic onset, to show familial associations, and to demonstrate expected correlations with psychosocial variables related to bipolar disorder. However, little work has been conducted to validate such measures against biologically relevant indices, or to consider whether early adversity, which has been shown to be highly elevated among those with bipolar disorder, is related to higher scores on mania risk measures. This study tested whether a well-used, self-report measure of vulnerability to mania is associated with several candidate genes that have previously been linked with bipolar disorder or with early adversity. Interactions of genes with early adversity in the prediction of mania vulnerability were also tested. Methods: Undergraduate students from the University of Miami (Coral Gables, FL, USA) (N = 305) completed the Hypomanic Personality Scale and the Risky Families Scale, and provided blood for genotyping. Results: Findings indicated that the Hypomanic Personality Scale was related to a number of dopamine-relevant polymorphisms and with early adversity. A polymorphism of ANKK1 appeared to specifically increase mania risk in the context of early adversity. Conclusions: These results provide additional support for the validity of the Hypomanic Personality Scale.

KW - Bipolar disorder

KW - Dopamine

KW - Early adversity

KW - Genetic polymorphism

KW - Mania risk

UR - http://www.scopus.com/inward/record.url?scp=84928206984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928206984&partnerID=8YFLogxK

U2 - 10.1111/bdi.12251

DO - 10.1111/bdi.12251

M3 - Article

C2 - 25219588

AN - SCOPUS:84928206984

VL - 17

SP - 331

EP - 339

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 3

ER -