A Gene Family-led Meta-Analysis of Drug-Target Interactions

Qiong Cheng; Saurabh Mehta; Stephan C Schuerer

doi:10.1109/BIBM.2018.8621087

A Gene Family-led Meta-Analysis of Drug-Target Interactions

Qiong Cheng, Saurabh Mehta, Stephan C Schuerer

Molecular and Cellular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The shift from 'magic bullets' to 'magic shotguns' has prospered the pharmaceutical industry, where a belief is that a drug that'hits' multiple sensitive nodes belonging to a network of interacting targets offers the potential for higher efficacy and may limit drawbacks arising from the use of a single-target drug or a combination of multiple drugs. More high-quality drug-target interactions, profiled by the 'magic shotguns' design paradigm, have emerged from diverse labs. However, the rapid production at scale and in variety challenges the efficacy of data usage. A creative and systematical approach is in demand to comprehensively analyze and integrate drug- target interactions for better prediction. In the project, taking the diversity into consideration, we carried out a gene family-led, meta-analysis, investigated diverse properties that drug-target pharmacological promiscuity relies on, and examined the consistency or integrity of drug-target data. The novel approach can facilitate the identification of cohesive multi-target combinations and revealed the interconnected properties of determining and rationalizing the promiscuity of profiled drugs. The approach can be further expanded to coordinate other experimental drug-target data and set a stage for the analysis of the mechanism of action of biological therapies.

Original language	English (US)
Title of host publication	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Editors	Harald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1618-1623
Number of pages	6
ISBN (Electronic)	9781538654880
DOIs	https://doi.org/10.1109/BIBM.2018.8621087
State	Published - Jan 21 2019
Event	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain Duration: Dec 3 2018 → Dec 6 2018

Publication series

Name	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

Conference

Conference	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Country	Spain
City	Madrid
Period	12/3/18 → 12/6/18

Keywords

drug-target interactions
information content
meta-analysis
ontology
polypharmocology

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics

Access to Document

10.1109/BIBM.2018.8621087

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Cite this

Cheng, Q., Mehta, S., & Schuerer, S. C. (2019). A Gene Family-led Meta-Analysis of Drug-Target Interactions. In H. Schmidt, D. Griol, H. Wang, J. Baumbach, H. Zheng, Z. Callejas, X. Hu, J. Dickerson, & L. Zhang (Eds.), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 (pp. 1618-1623). [8621087] (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2018.8621087

A Gene Family-led Meta-Analysis of Drug-Target Interactions. / Cheng, Qiong; Mehta, Saurabh; Schuerer, Stephan C.

Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. ed. / Harald Schmidt; David Griol; Haiying Wang; Jan Baumbach; Huiru Zheng; Zoraida Callejas; Xiaohua Hu; Julie Dickerson; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1618-1623 8621087 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cheng, Q, Mehta, S & Schuerer, SC 2019, A Gene Family-led Meta-Analysis of Drug-Target Interactions. in H Schmidt, D Griol, H Wang, J Baumbach, H Zheng, Z Callejas, X Hu, J Dickerson & L Zhang (eds), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018., 8621087, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Institute of Electrical and Electronics Engineers Inc., pp. 1618-1623, 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Madrid, Spain, 12/3/18. https://doi.org/10.1109/BIBM.2018.8621087

Cheng Q, Mehta S, Schuerer SC. A Gene Family-led Meta-Analysis of Drug-Target Interactions. In Schmidt H, Griol D, Wang H, Baumbach J, Zheng H, Callejas Z, Hu X, Dickerson J, Zhang L, editors, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1618-1623. 8621087. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). https://doi.org/10.1109/BIBM.2018.8621087

Cheng, Qiong ; Mehta, Saurabh ; Schuerer, Stephan C. / A Gene Family-led Meta-Analysis of Drug-Target Interactions. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. editor / Harald Schmidt ; David Griol ; Haiying Wang ; Jan Baumbach ; Huiru Zheng ; Zoraida Callejas ; Xiaohua Hu ; Julie Dickerson ; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1618-1623 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

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