@inproceedings{521c0a06c6f849ab83b56668d52d14bb,
title = "A Gene Family-led Meta-Analysis of Drug-Target Interactions",
abstract = "The shift from 'magic bullets' to 'magic shotguns' has prospered the pharmaceutical industry, where a belief is that a drug that'hits' multiple sensitive nodes belonging to a network of interacting targets offers the potential for higher efficacy and may limit drawbacks arising from the use of a single-target drug or a combination of multiple drugs. More high-quality drug-target interactions, profiled by the 'magic shotguns' design paradigm, have emerged from diverse labs. However, the rapid production at scale and in variety challenges the efficacy of data usage. A creative and systematical approach is in demand to comprehensively analyze and integrate drug- target interactions for better prediction. In the project, taking the diversity into consideration, we carried out a gene family-led, meta-analysis, investigated diverse properties that drug-target pharmacological promiscuity relies on, and examined the consistency or integrity of drug-target data. The novel approach can facilitate the identification of cohesive multi-target combinations and revealed the interconnected properties of determining and rationalizing the promiscuity of profiled drugs. The approach can be further expanded to coordinate other experimental drug-target data and set a stage for the analysis of the mechanism of action of biological therapies.",
keywords = "drug-target interactions, information content, meta-analysis, ontology, polypharmocology",
author = "Qiong Cheng and Saurabh Mehta and Schuerer, {Stephan C}",
year = "2019",
month = jan,
day = "21",
doi = "10.1109/BIBM.2018.8621087",
language = "English (US)",
series = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1618--1623",
editor = "Harald Schmidt and David Griol and Haiying Wang and Jan Baumbach and Huiru Zheng and Zoraida Callejas and Xiaohua Hu and Julie Dickerson and Le Zhang",
booktitle = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",
note = "2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 ; Conference date: 03-12-2018 Through 06-12-2018",
}