A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders

Jackson Saraf, Pallab Bhattacharya, Kiran Kalia, Anupom Borah, Deepaneeta Sarmah, Harpreet Kaur, Kunjan R. Dave, Dileep R. Yavagal

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.

Original languageEnglish (US)
Pages (from-to)805-819
Number of pages15
JournalACS Central Science
Volume4
Issue number7
DOIs
StatePublished - Jul 25 2018

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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