A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders

Jackson Saraf; Pallab Bhattacharya; Kiran Kalia; Anupom Borah; Deepaneeta Sarmah; Harpreet Kaur; Kunjan R. Dave; Dileep R. Yavagal

doi:10.1021/acscentsci.8b00230

A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders

Jackson Saraf, Pallab Bhattacharya, Kiran Kalia, Anupom Borah, Deepaneeta Sarmah, Harpreet Kaur, Kunjan R. Dave, Dileep R. Yavagal

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.

Original language	English (US)
Pages (from-to)	805-819
Number of pages	15
Journal	ACS Central Science
Volume	4
Issue number	7
DOIs	https://doi.org/10.1021/acscentsci.8b00230
State	Published - Jul 25 2018

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1021/acscentsci.8b00230

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title = "A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders",

abstract = "The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.",

author = "Jackson Saraf and Pallab Bhattacharya and Kiran Kalia and Anupom Borah and Deepaneeta Sarmah and Harpreet Kaur and Dave, {Kunjan R.} and Yavagal, {Dileep R.}",

note = "Funding Information: The authors acknowledge Department of Science and Technology (DST), Government of India, for their financial support through Grant (SB/YS/LS-196/2014), International Society for Neurochemistry (ISN) Return Home Grant, Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Government of India, and National Institute of Pharmaceutical Education and Research (NIPER) Ahmeda-bad, Gandhinagar, India. The authors also want to express their thanks to Prof. Larry Benowitz, Boston Children{\textquoteright}s Hospital, Harvard Medical School, Boston, MA, United States, and the Director, NIPER Ahmedabad, for providing necessary support. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

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AU - Dave, Kunjan R.

AU - Yavagal, Dileep R.

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A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders

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