Abstract
The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 805-819 |
| Number of pages | 15 |
| Journal | ACS Central Science |
| Volume | 4 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 25 2018 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
A Friend or Foe : Calcineurin across the Gamut of Neurological Disorders. / Saraf, Jackson; Bhattacharya, Pallab; Kalia, Kiran; Borah, Anupom; Sarmah, Deepaneeta; Kaur, Harpreet; Dave, Kunjan R; Yavagal, Dileep R.
In: ACS Central Science, Vol. 4, No. 7, 25.07.2018, p. 805-819.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Friend or Foe
T2 - Calcineurin across the Gamut of Neurological Disorders
AU - Saraf, Jackson
AU - Bhattacharya, Pallab
AU - Kalia, Kiran
AU - Borah, Anupom
AU - Sarmah, Deepaneeta
AU - Kaur, Harpreet
AU - Dave, Kunjan R
AU - Yavagal, Dileep R
PY - 2018/7/25
Y1 - 2018/7/25
N2 - The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.
AB - The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.
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U2 - 10.1021/acscentsci.8b00230
DO - 10.1021/acscentsci.8b00230
M3 - Article
AN - SCOPUS:85050556465
VL - 4
SP - 805
EP - 819
JO - ACS Central Science
JF - ACS Central Science
SN - 2374-7943
IS - 7
ER -