A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?

Susan L. Limbu, Talveen S. Purba, Matthew Harries, Tongyu C. Wikramanayake, Mariya Miteva, Ranjit K. Bhogal, Catherine A. O'Neill, Ralf Paus

Research output: Contribution to journalArticlepeer-review

Abstract

Dandruff is a common scalp condition, which frequently causes psychological distress in those affected. Dandruff is considered to be caused by an interplay of several factors. However, the pathogenesis of dandruff remains under-investigated, especially with respect to the contribution of the hair follicle. As the hair follicle exhibits unique immune-modulatory properties, including the creation of an immunoinhibitory, immune-privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of yeast and bacterial species, along with increasing proinflammatory sebum by-products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune-microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: https://youtu.be/mEZEznCYtNs.

Original languageEnglish (US)
Article number2100005
JournalBioEssays
Volume43
Issue number10
DOIs
StatePublished - Oct 2021
Externally publishedYes

Keywords

  • dandruff
  • hair follicle
  • immune privilege
  • inflammation
  • keratinocytes
  • seborrheic dermatitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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