A feasibility study of deep learning for predicting hemodynamics of human thoracic aorta

Liang Liang, Wenbin Mao, Wei Sun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Numerical analysis methods including finite element analysis (FEA), computational fluid dynamics (CFD), and fluid–structure interaction (FSI) analysis have been used to study the biomechanics of human tissues and organs, as well as tissue-medical device interactions, and treatment strategies. However, for patient-specific computational analysis, complex procedures are usually required to set-up the models, and long computing time is needed to perform the simulation, preventing fast feedback to clinicians in time-sensitive clinical applications. In this study, by using machine learning techniques, we developed deep neural networks (DNNs) to directly estimate the steady-state distributions of pressure and flow velocity inside the thoracic aorta. After training on hemodynamic data from CFD simulations, the DNNs take as input a shape of the aorta and directly output the hemodynamic distributions in one second. The trained DNNs are capable of predicting the velocity magnitude field with an average error of 1.9608% and the pressure field with an average error of 1.4269%. This study demonstrates the feasibility and great potential of using DNNs as a fast and accurate surrogate model for hemodynamic analysis of large blood vessels.

Original languageEnglish (US)
Article number109544
JournalJournal of Biomechanics
StatePublished - Jan 23 2020


  • Computational fluid dynamics
  • Deep neural network
  • Hemodynamic analysis
  • Machine learning

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rehabilitation


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