A fatalepizootic of undetermined etiology in new world monkeys

M. J. Kessler, R. J. Brown, S. S. Kalter, N. H. Altman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A peracute epizootic disease, strikingly characterized by profuse terminal hemorrhaging from the lungs, caused the deaths of 104 squirrel monkeys and 3 capuchin monkeys over a 22-month period. The case fatality rate was 100%. The pulmonary hemorrhaging was often accompanied by pulmonary edema and congestion, interstitial pneumonia, and hydrothorax. Additional histologic lesions included interstitial nephritis, hepatitis and hepatic necrosis, adrenalitis and adrenal necrosis, myocarditis, splenic atrophy or hypoplasia, pancreatitis and pancreatic necrosis, sialoadenitis, and encephalitis. Macaques maintained under identical conditions were clinically unaffected by the epizootic. There was an incidental relationship with contamination of feed, water, and housing facilities by excrement from feral Norway rats and cockroaches. Due to the association of the disease outbreak with abundant rodent and cockroach populations, and because the histologic features of the disease were suggestive of a viral etiology, encephalomyocarditis virus infection was implicated. However, histopathologic examinations of tissues from 68 monkeys; electron-microscopic studies on five monkeys; bacterologic culturing; virus isolation attempts from 10 monkeys, rats, and cockroaches; and experimental inoculation studies in mice and squirrel monkeys all failed to reveal the causative agent, to provide a definitive diagnosis, or to reproduce the disease.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalAmerican Journal of Primatology
Volume3
Issue number1-4
StatePublished - Dec 1 1982
Externally publishedYes

Fingerprint

Cebidae
etiology
Blattodea
cockroach
monkeys
necrosis
Saimiri
lungs
Encephalomyocarditis virus
myocarditis
virus
nephritis
feed contamination
pancreatitis
Cebus
Rattus norvegicus
hepatitis
encephalitis
excreta
atrophy

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Kessler, M. J., Brown, R. J., Kalter, S. S., & Altman, N. H. (1982). A fatalepizootic of undetermined etiology in new world monkeys. American Journal of Primatology, 3(1-4), 253-261.

A fatalepizootic of undetermined etiology in new world monkeys. / Kessler, M. J.; Brown, R. J.; Kalter, S. S.; Altman, N. H.

In: American Journal of Primatology, Vol. 3, No. 1-4, 01.12.1982, p. 253-261.

Research output: Contribution to journalArticle

Kessler, MJ, Brown, RJ, Kalter, SS & Altman, NH 1982, 'A fatalepizootic of undetermined etiology in new world monkeys', American Journal of Primatology, vol. 3, no. 1-4, pp. 253-261.
Kessler MJ, Brown RJ, Kalter SS, Altman NH. A fatalepizootic of undetermined etiology in new world monkeys. American Journal of Primatology. 1982 Dec 1;3(1-4):253-261.
Kessler, M. J. ; Brown, R. J. ; Kalter, S. S. ; Altman, N. H. / A fatalepizootic of undetermined etiology in new world monkeys. In: American Journal of Primatology. 1982 ; Vol. 3, No. 1-4. pp. 253-261.
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