A FATAL ENCEPHALOPATHY IN CHRONIC HÆMODIALYSIS PATIENTS

Jack S. Burks, John Huddlestone, Allen C. Alfrey, Michael D. Norenberg, Edward Lewin

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

A distinct neurological syndrome in twelve chronic hæmodialysis patients is described. This syndrome is currently the leading cause of death in one Denver dialysis unit. The hallmarks of this syndrome are progressive speech difficulties, mental changes, and a markedly abnormal electroencephalogram which may be present months before the clinical signs appear. Additional clinical features including seizures, myoclonus, asterixis, apraxia, focal neurological signs, and psychiatric symptoms may also be observed. Neuropathological changes are slight and non-specific, The ætiology of this syndrome is unknown but the clinical and pathological features suggest a toxic/metabolic disorder. To date, this disorder has been refractory to several therapeutic measures.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalThe Lancet
Volume307
Issue number7963
DOIs
StatePublished - Apr 10 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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