A family of chromatin remodeling factors related to Williams syndrome transcription factor

Daniel A. Bochar; Julie Savard; Weidong Wang; David W. Lafleur; Paul Moore; Jacques Côté; Ramin Shiekhattar

doi:10.1073/pnas.97.3.1038

A family of chromatin remodeling factors related to Williams syndrome transcription factor

Daniel A. Bochar, Julie Savard, Weidong Wang, David W. Lafleur, Paul Moore, Jacques Côté, Ramin Shiekhattar

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124 Scopus citations

Abstract

Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

Original language	English (US)
Pages (from-to)	1038-1043
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	3
DOIs	https://doi.org/10.1073/pnas.97.3.1038
State	Published - Feb 1 2000
Externally published	Yes

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A family of chromatin remodeling factors related to Williams syndrome transcription factor. / Bochar, Daniel A.; Savard, Julie; Wang, Weidong; Lafleur, David W.; Moore, Paul; Côté, Jacques; Shiekhattar, Ramin.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 3, 01.02.2000, p. 1038-1043.

Research output: Contribution to journal › Article › peer-review

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AU - Shiekhattar, Ramin

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A family of chromatin remodeling factors related to Williams syndrome transcription factor

Abstract

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