A family of chromatin remodeling factors related to Williams syndrome transcription factor

Daniel A. Bochar, Julie Savard, Weidong Wang, David W. Lafleur, Paul Moore, Jacques Côté, Ramin Shiekhattar

Research output: Contribution to journalArticle

123 Scopus citations


Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

Original languageEnglish (US)
Pages (from-to)1038-1043
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
StatePublished - Feb 1 2000
Externally publishedYes


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  • General

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