Abstract
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1038-1043 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
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A family of chromatin remodeling factors related to Williams syndrome transcription factor. / Bochar, Daniel A.; Savard, Julie; Wang, Weidong; Lafleur, David W.; Moore, Paul; Côté, Jacques; Shiekhattar, Ramin.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 3, 01.02.2000, p. 1038-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A family of chromatin remodeling factors related to Williams syndrome transcription factor
AU - Bochar, Daniel A.
AU - Savard, Julie
AU - Wang, Weidong
AU - Lafleur, David W.
AU - Moore, Paul
AU - Côté, Jacques
AU - Shiekhattar, Ramin
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.
AB - Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033965391&partnerID=8YFLogxK
U2 - 10.1073/pnas.97.3.1038
DO - 10.1073/pnas.97.3.1038
M3 - Article
VL - 97
SP - 1038
EP - 1043
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 3
ER -