A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes

Laurent Lavanant, Brian Pullin, Jeffrey A. Hubbell, Harm Anton Klok

Research output: Contribution to journalArticle

41 Scopus citations


This manuscript reports a facile strategy for the modification of polyethylene, a widely used biomaterial, with a thin non-biofouling coating that can act as a platform to introduce biochemical cues to control and direct, e.g., cell adhesion and proliferation. The non-biofouling coating is produced, following a two-step strategy involving photobromination of the polyethylene substrate followed by surface-initiated ATRP of poly(ethylene glycol) methacrylate. The resulting coatings, which are referred to as polymer brushes, are robust and withstand prolonged exposure to aqueous ethanol and phosphate buffered saline and also do not show any signs of detachment or degradation in the in vivo studies over a period of 10 d. Functionalization of these polymer brush coatings with extracellular matrix derived peptide sequences, promotes adhesion and spreading of endothelial cells. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalMacromolecular Bioscience
Issue number1
StatePublished - Jan 11 2010
Externally publishedYes



  • Atom transfer radical polymerization (ATRP)
  • Bromination
  • Cell adhesion
  • Polyethylene (PE)
  • Polymer brushes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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