A double-blind controlled trial of bovine brain gangliosides in amyotrophic lateral sclerosis

W. G. Bradley, W. Hedlund, C. Cooper, G. J. Desousa, A. Gabbai, J. S. Mora, T. L. Munsat, R. Scheife

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33 Scopus citations

Abstract

We conducted a double-blind controlled study of the effect of brain gangliosides in amyotrophic lateral sclerosis. Nineteen patients received intramuscular gangliosides (40 mg/d) for 6 months, and 21 received placebo. The deterioration rates for approximately 120 clinical and electrophysiologic parameters of neuromuscular function were analyzed, but no statistically significant beneficial effect of the drug was demonstrated. However, the large coefficient of variation for each item indicated that a sample size of several hundred patients would have been necessary to exclude the possibility that the drug produced a 25% slowing of progression of the disease.

Original languageEnglish (US)
Pages (from-to)1079-1082
Number of pages4
JournalNeurology
Volume34
Issue number8
StatePublished - Aug 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Bradley, W. G., Hedlund, W., Cooper, C., Desousa, G. J., Gabbai, A., Mora, J. S., Munsat, T. L., & Scheife, R. (1984). A double-blind controlled trial of bovine brain gangliosides in amyotrophic lateral sclerosis. Neurology, 34(8), 1079-1082.