A direct enzyme-linked immunoassay (ELISA), based on the 'sandwich' principle on an antigen-coated plastic disc, was used for the rapid detection of rubella antibody. Results were obtained the same day, and the prior adsorption of sera to remove non-specific inhibitors was not necessary. The ELISA was compared to the hemagglutination-inhibition (HAI) test on 500 serum samples. There was general agreement between the two methods; most discrepancies occurred with low-titered HAI positive sera. There was excellent correlation between the tests with serum samples negative for rubella antibodies and those samples with HAI titres ≥ 1:40.
|Original language||English (US)|
|Number of pages||13|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Dec 1 1978|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)