'A detective look' at hair biopsies from African-American patients

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: A patient's ethnicity can be an important clue in the diagnosis of scarring alopecia as some disorders such as traction alopecia (TA) and central centrifugal cicatricial alopecia (CCCA) are more prevalent in or exclusive to African-Americans. Objectives: To perform a retrospective review of 60 scalp biopsies from African-American patients including 25 cases of CCCA, 22 cases of TA, five cases of frontal fibrosing alopecia, three cases of discoid lupus erythematosus, three cases of hair breakage and two cases of alopecia areata. Methods Serial horizontal and vertical sections were examined. Results: Features characteristic of the African-American scalp include: golf club-shaped bulb, elliptical shape of the hair shaft, asymmetrical outer root sheath and paired grouping of hair follicles. Clues to the diagnosis of CCCA include: premature desquamation of the inner root sheath, goggles and naked hair shafts in fibrous streamers. Diagnosis of TA is suggested by preserved sebaceous glands along with follicular miniaturization and drop-out. Conclusions: The clues reported here aim to help the dermatopathologists to: recognize at a glance that they are dealing with a scalp biopsy from an African-American patient; make the most probable diagnosis by connecting the clues (even if only vertical sections are present); and understand the morphological basis for the susceptibility of the African hair to damage.

Original languageEnglish
Pages (from-to)1289-1294
Number of pages6
JournalBritish Journal of Dermatology
Volume166
Issue number6
DOIs
StatePublished - Jun 1 2012

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Alopecia
African Americans
Hair
Biopsy
Traction
Scalp
Eye Protective Devices
Discoid Lupus Erythematosus
Golf
Miniaturization
Alopecia Areata
Sebaceous Glands
Hair Follicle
Cicatrix

ASJC Scopus subject areas

  • Dermatology

Cite this

'A detective look' at hair biopsies from African-American patients. / Miteva, Mariya; Tosti, Antonella.

In: British Journal of Dermatology, Vol. 166, No. 6, 01.06.2012, p. 1289-1294.

Research output: Contribution to journalArticle

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