A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors.

K. Nielsen, G. McSherry, A. Petru, T. Frederick, D. Wara, Y. Bryson, N. Martin, C. Hutto, A. J. Ammann, S. Grubman, J. Oleske, Gwendolyn B Scott

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To identify the population of human immunodeficiency virus-infected pediatric long- term survivors (LTS) followed in major medical institutions in California, Florida and New Jersey. METHODS: A cross-sectional survey was performed with data collection forms sent to all investigators. Demographic, clinical, and laboratory data were obtained on all living patients >/=8 years infected in the perinatal period with human immunodeficiency virus. RESULTS: A total of 143 perinatally infected and 54 children infected by neonatal transfusion were identified. Fifty-four children (27%) had absolute CD4 counts >/=500 cells/mm (group 1: mean age 9.8 years), 54 children (27%) had CD4 counts between 200 and 500 cells/mm (group 2: mean age 10.1 years), and 89 children (45%) had CD4 counts <200 cells/mm (group 3: mean age 10.4 years). Ninety-five (48%) patients had developed AIDS defining conditions; 14 (26%) in group 1, 26 (48%) in group 2, and 55 (62%) in group 3. Ninety-two percent of patients had received antiretrovirals. Perinatally human immunodeficiency virus-infected children tended to be younger (mean age 9.8 years) than children infected via a blood transfusion (mean age 11 years). Generalized lymphadenopathy was the most prevalent clinical finding. Lymphoid interstitial pneumonia and recurrent bacterial infections were the most prevalent acquired immune deficiency syndrome-defining conditions. Twenty percent of LTS had CD4 counts >/=500 cells/mm and no immune deficiency syndrome-defining conditions. CONCLUSIONS: Pediatric LTS were in variable stages of disease progression. The proportion of children within each CD4 strata did not differ by mode of acquisition of infection. Increased CD4 counts were inversely proportional to age. Only 20% of pediatric LTS had minimal to no disease progression.

Original languageEnglish
JournalPediatrics
Volume99
Issue number4
StatePublished - Apr 1 1997
Externally publishedYes

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Survivors
CD4 Lymphocyte Count
HIV
Pediatrics
Disease Progression
Cross-Sectional Studies
Research Personnel
Demography
Surveys and Questionnaires
Infection
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nielsen, K., McSherry, G., Petru, A., Frederick, T., Wara, D., Bryson, Y., ... Scott, G. B. (1997). A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. Pediatrics, 99(4).

A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. / Nielsen, K.; McSherry, G.; Petru, A.; Frederick, T.; Wara, D.; Bryson, Y.; Martin, N.; Hutto, C.; Ammann, A. J.; Grubman, S.; Oleske, J.; Scott, Gwendolyn B.

In: Pediatrics, Vol. 99, No. 4, 01.04.1997.

Research output: Contribution to journalArticle

Nielsen, K, McSherry, G, Petru, A, Frederick, T, Wara, D, Bryson, Y, Martin, N, Hutto, C, Ammann, AJ, Grubman, S, Oleske, J & Scott, GB 1997, 'A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors.', Pediatrics, vol. 99, no. 4.
Nielsen K, McSherry G, Petru A, Frederick T, Wara D, Bryson Y et al. A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. Pediatrics. 1997 Apr 1;99(4).
Nielsen, K. ; McSherry, G. ; Petru, A. ; Frederick, T. ; Wara, D. ; Bryson, Y. ; Martin, N. ; Hutto, C. ; Ammann, A. J. ; Grubman, S. ; Oleske, J. ; Scott, Gwendolyn B. / A descriptive survey of pediatric human immunodeficiency virus-infected long-term survivors. In: Pediatrics. 1997 ; Vol. 99, No. 4.
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abstract = "OBJECTIVE: To identify the population of human immunodeficiency virus-infected pediatric long- term survivors (LTS) followed in major medical institutions in California, Florida and New Jersey. METHODS: A cross-sectional survey was performed with data collection forms sent to all investigators. Demographic, clinical, and laboratory data were obtained on all living patients >/=8 years infected in the perinatal period with human immunodeficiency virus. RESULTS: A total of 143 perinatally infected and 54 children infected by neonatal transfusion were identified. Fifty-four children (27{\%}) had absolute CD4 counts >/=500 cells/mm (group 1: mean age 9.8 years), 54 children (27{\%}) had CD4 counts between 200 and 500 cells/mm (group 2: mean age 10.1 years), and 89 children (45{\%}) had CD4 counts <200 cells/mm (group 3: mean age 10.4 years). Ninety-five (48{\%}) patients had developed AIDS defining conditions; 14 (26{\%}) in group 1, 26 (48{\%}) in group 2, and 55 (62{\%}) in group 3. Ninety-two percent of patients had received antiretrovirals. Perinatally human immunodeficiency virus-infected children tended to be younger (mean age 9.8 years) than children infected via a blood transfusion (mean age 11 years). Generalized lymphadenopathy was the most prevalent clinical finding. Lymphoid interstitial pneumonia and recurrent bacterial infections were the most prevalent acquired immune deficiency syndrome-defining conditions. Twenty percent of LTS had CD4 counts >/=500 cells/mm and no immune deficiency syndrome-defining conditions. CONCLUSIONS: Pediatric LTS were in variable stages of disease progression. The proportion of children within each CD4 strata did not differ by mode of acquisition of infection. Increased CD4 counts were inversely proportional to age. Only 20{\%} of pediatric LTS had minimal to no disease progression.",
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AU - Martin, N.

AU - Hutto, C.

AU - Ammann, A. J.

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AU - Scott, Gwendolyn B

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