A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors

Karin Nielsen, George McSherry, Ann Petru, Toni Frederick, Diane Wara, Yvonne Bryson, Natasha Martin, Cecelia Hutto, Arthur J. Ammann, Samuel Grubman, James Oleske, Gwendolyn B Scott

Research output: Contribution to journalArticle

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Abstract

Objective. To identify the population of human immunodeficiency virus-infected pediatric long- term survivors (LTS) followed in major medical institutions in California, Florida and New Jersey. Methods. A cross-sectional survey was performed with data collection forms sent to all investigators. Demographic, clinical, and laboratory data were obtained on all living patients &8 years infected in the perinatal period with human immunodeficiency virus. Results. A total of 143 perinatally infected and 54 children infected by neonatal transfusion were identified. Fifty-four children (27%) had absolute CD4 counts 2:500 cells/mm3 (group 1: mean age 9.8 years), 54 children (27%) had CD4 counts between 200 and 500 cells/mm3 (group 2: mean age 10.1 years), and 89 children (45%) had CD4 counts <200 cells/mm3 (group 3: mean age 10.4 years). Ninety-five (48%) patients had developed AIDS defining conditions; 14 (26%) in group 1, 26 (48%) in group 2, and 55 (62%) in group 3. Ninety-two percent of patients had received antiretrovirals. Perinatally human immunodeficiency virus-infected children tended to be younger (mean age 9.8 years) than children infected via a blood transfusion (mean age 11 years). Generalized lymphadenopathy was the most prevalent clinical finding. Lymphoid interstitial pneumonia and recurrent bacterial infections were the most prevalent acquired immune deficiency syndrome-defining conditions. Twenty percent of LTS had CD4 counts a500 cells/mm3 and no immune deficiency syndrome-defining conditions. Conclusions. Pédiatrie LTS were in variable stages of disease progression. The proportion of children within each CD4 strata did not differ by mode of acquisition of infection. Increased CD4 counts were inversely proportional to age. Only 20% of pediatric LTS had minimal to no disease progression. Pediatrics 1997;99(4). URL: http: //www.pediatrics.org/cgi/content/full/99/4/e4; HIV, pediatric long-term survivors, slow disease progression.

Original languageEnglish
Pages (from-to)593-594
Number of pages2
JournalPediatrics
Volume99
Issue number4
StatePublished - Dec 1 1997
Externally publishedYes

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Survivors
CD4 Lymphocyte Count
HIV
Pediatrics
Disease Progression
HIV Long-Term Survivors
Acquired Immunodeficiency Syndrome
Surveys and Questionnaires
Bacterial Infections
Blood Transfusion
Cross-Sectional Studies
Research Personnel
Demography
Infection
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nielsen, K., McSherry, G., Petru, A., Frederick, T., Wara, D., Bryson, Y., ... Scott, G. B. (1997). A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors. Pediatrics, 99(4), 593-594.

A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors. / Nielsen, Karin; McSherry, George; Petru, Ann; Frederick, Toni; Wara, Diane; Bryson, Yvonne; Martin, Natasha; Hutto, Cecelia; Ammann, Arthur J.; Grubman, Samuel; Oleske, James; Scott, Gwendolyn B.

In: Pediatrics, Vol. 99, No. 4, 01.12.1997, p. 593-594.

Research output: Contribution to journalArticle

Nielsen, K, McSherry, G, Petru, A, Frederick, T, Wara, D, Bryson, Y, Martin, N, Hutto, C, Ammann, AJ, Grubman, S, Oleske, J & Scott, GB 1997, 'A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors', Pediatrics, vol. 99, no. 4, pp. 593-594.
Nielsen K, McSherry G, Petru A, Frederick T, Wara D, Bryson Y et al. A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors. Pediatrics. 1997 Dec 1;99(4):593-594.
Nielsen, Karin ; McSherry, George ; Petru, Ann ; Frederick, Toni ; Wara, Diane ; Bryson, Yvonne ; Martin, Natasha ; Hutto, Cecelia ; Ammann, Arthur J. ; Grubman, Samuel ; Oleske, James ; Scott, Gwendolyn B. / A descriptive survey of pédiatrie human immunodeficiency virus-infected long-term survivors. In: Pediatrics. 1997 ; Vol. 99, No. 4. pp. 593-594.
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AU - Bryson, Yvonne

AU - Martin, Natasha

AU - Hutto, Cecelia

AU - Ammann, Arthur J.

AU - Grubman, Samuel

AU - Oleske, James

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