A description of parasite-harbouring cells in localized lymphadenitis in dry type cutaneous leishmaniasis

S. Dabiri, S. S. Meymandi, Mehrdad Nadji, A. Kharazmi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lymphadenitis with or without dry-type cutaneous leishmaniasis is rare. The lesion might self heal or show excellent response to antimonial therapy. Routine histopathological changes of localized leishmaniasis lymphadenitis are non-caseating to suppurative granulomata mostly in paracortical areas, some with extension to germinal centres, medullary cords and/or pericapsular spaces which have to be distinguished from other causes of lymphadenitis such as tuberculosis, cat-scratch disease and toxoplasmosis. Dense lymphoplasmocytic infiltrate was observed surrounding the necrotizing granuloma together with dense capsular fibrosis with multiple granulomata in subcapsular and pericapsular areas. Immunostaining of lymph nodes showed that a few macrophages were harbouring Leishman bodies. Dispersed Langerhans cells were also harbouring Leishman bodies in the parasitophorous vacuoles between their cytoplasmic pseudopods. In conclusion multiple noncaseating to suppurative granulomata with dense pericapsular and capsular granulomo-sclerotic changes should be considered in the differential diagnosis of leishmaniasis lymphadenitis.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalActa Tropica
Volume79
Issue number2
DOIs
StatePublished - May 25 2001

Fingerprint

lymphadenitis
cutaneous leishmaniasis
Lymphadenitis
Cutaneous Leishmaniasis
granuloma
Granuloma
Parasites
parasites
Leishmaniasis
leishmaniasis
cat scratch disease
cells
Cat-Scratch Disease
Langerhans cells
pseudopodia
Pseudopodia
Germinal Center
Langerhans Cells
toxoplasmosis
Toxoplasmosis

Keywords

  • Histopathology
  • Langerhans cells
  • Leishmania tropica
  • Lymphadenitis
  • Macrophage

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

A description of parasite-harbouring cells in localized lymphadenitis in dry type cutaneous leishmaniasis. / Dabiri, S.; Meymandi, S. S.; Nadji, Mehrdad; Kharazmi, A.

In: Acta Tropica, Vol. 79, No. 2, 25.05.2001, p. 129-133.

Research output: Contribution to journalArticle

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