A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay

Marc E Lippman, K. Huff

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Separate receptors for estrogen and androgen are demonstrated in cells from metastatic human breast cancer. By criteria of binding affinity, number of binding sites, and specificity of the receptor for different steroids, the receptors are shown to be distinguishable. The protamine sulfate receptor assay technique employed allows both kinds of receptor to be quantified conveniently and reproducibly without interference by plasma steroid binding components.

Original languageEnglish
Pages (from-to)868-874
Number of pages7
JournalCancer
Volume38
Issue number2
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Protamines
Steroid Receptors
Androgen Receptors
Estrogen Receptors
Steroids
Binding Sites
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay. / Lippman, Marc E; Huff, K.

In: Cancer, Vol. 38, No. 2, 01.12.1976, p. 868-874.

Research output: Contribution to journalArticle

@article{5872dada0ddd4c2bba39f529cf020ad4,
title = "A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay",
abstract = "Separate receptors for estrogen and androgen are demonstrated in cells from metastatic human breast cancer. By criteria of binding affinity, number of binding sites, and specificity of the receptor for different steroids, the receptors are shown to be distinguishable. The protamine sulfate receptor assay technique employed allows both kinds of receptor to be quantified conveniently and reproducibly without interference by plasma steroid binding components.",
author = "Lippman, {Marc E} and K. Huff",
year = "1976",
month = "12",
day = "1",
language = "English",
volume = "38",
pages = "868--874",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay

AU - Lippman, Marc E

AU - Huff, K.

PY - 1976/12/1

Y1 - 1976/12/1

N2 - Separate receptors for estrogen and androgen are demonstrated in cells from metastatic human breast cancer. By criteria of binding affinity, number of binding sites, and specificity of the receptor for different steroids, the receptors are shown to be distinguishable. The protamine sulfate receptor assay technique employed allows both kinds of receptor to be quantified conveniently and reproducibly without interference by plasma steroid binding components.

AB - Separate receptors for estrogen and androgen are demonstrated in cells from metastatic human breast cancer. By criteria of binding affinity, number of binding sites, and specificity of the receptor for different steroids, the receptors are shown to be distinguishable. The protamine sulfate receptor assay technique employed allows both kinds of receptor to be quantified conveniently and reproducibly without interference by plasma steroid binding components.

UR - http://www.scopus.com/inward/record.url?scp=0017178420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017178420&partnerID=8YFLogxK

M3 - Article

C2 - 975004

AN - SCOPUS:0017178420

VL - 38

SP - 868

EP - 874

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 2

ER -