A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay

Marc Lippman, Karen Huff

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Separate receptors for estrogen and androgen are demonstrated in cells from metastatic human breast cancer. By criteria of binding affinity, number of binding sites, and specificity of the receptor for different steroids, the receptors are shown to be distinguishable. The protamine sulfate receptor assay technique employed allows both kinds of receptor to be quantified conveniently and reproducibly without interference by plasma steroid binding components.

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
JournalCancer
Volume38
Issue number2
DOIs
StatePublished - Aug 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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