A Deconvolution Technique for Improved Estimation of Rapid Changes in Ion Concentration Recorded with Ion-Selective Microelectrodes

Jeffrey L. Tucker, Rong Wen, Burks Oakley

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In biological preparations, measurements of rapid, stimulus-evoked changes in ion concentration by ion-selective microelectrodes can be distorted by the limited bandwidth of these sensors. Techniques were developed to reconstruct the actual change in ion concentration using deconvolution of the electrode's output signal and the electrode's transfer function. In the vertebrate retina, a knowledge of the actual time course of a light-evoked increase in extracellular K+ concentration was used to provide a rigorous test of a hypothesis regarding the electrical origin of a clinically important component of the electroretinogram.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalIEEE Transactions on Biomedical Engineering
Volume38
Issue number2
DOIs
StatePublished - Feb 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering

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