A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

H. Tsubota, C. I. Lord, David Watkins, C. Morimoto, N. L. Letvin

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIV(mac)) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.

Original languageEnglish
Pages (from-to)1421-1434
Number of pages14
JournalJournal of Experimental Medicine
Volume169
Issue number4
StatePublished - Jan 1 1989
Externally publishedYes

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Cytotoxic T-Lymphocytes
Virus Replication
HIV
Lymphocytes
Lymphocyte Function-Associated Antigen-1
Simian Immunodeficiency Virus
Macaca
Virus Diseases
Integrins
HIV-1
Epitopes
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes. / Tsubota, H.; Lord, C. I.; Watkins, David; Morimoto, C.; Letvin, N. L.

In: Journal of Experimental Medicine, Vol. 169, No. 4, 01.01.1989, p. 1421-1434.

Research output: Contribution to journalArticle

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