A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

H. Tsubota; C. I. Lord; D. I. Watkins; C. Morimoto; N. L. Letvin

doi:10.1084/jem.169.4.1421

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

H. Tsubota, C. I. Lord, D. I. Watkins, C. Morimoto, N. L. Letvin

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

CD8⁺ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIV(mac)) in PBL of infected individuals. We now show that these CD8⁺ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8⁺ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8⁺ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.

Original language	English (US)
Pages (from-to)	1421-1434
Number of pages	14
Journal	Journal of Experimental Medicine
Volume	169
Issue number	4
DOIs	https://doi.org/10.1084/jem.169.4.1421
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1084/jem.169.4.1421

Fingerprint Dive into the research topics of 'A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes'. Together they form a unique fingerprint.

Cite this

@article{9f983a2af28f42b188a7d3a421ba15f3,

title = "A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes",

abstract = "CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIV(mac)) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.",

author = "H. Tsubota and Lord, {C. I.} and Watkins, {D. I.} and C. Morimoto and Letvin, {N. L.}",

year = "1989",

doi = "10.1084/jem.169.4.1421",

language = "English (US)",

volume = "169",

pages = "1421--1434",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

number = "4",

}

TY - JOUR

T1 - A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

AU - Tsubota, H.

AU - Lord, C. I.

AU - Watkins, D. I.

AU - Morimoto, C.

AU - Letvin, N. L.

PY - 1989

Y1 - 1989

N2 - CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIV(mac)) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.

AB - CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIV(mac)) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.

UR - http://www.scopus.com/inward/record.url?scp=0024573301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024573301&partnerID=8YFLogxK

U2 - 10.1084/jem.169.4.1421

DO - 10.1084/jem.169.4.1421

M3 - Article

C2 - 2784486

AN - SCOPUS:0024573301

VL - 169

SP - 1421

EP - 1434

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 4

ER -