@inbook{0a649bdde0c64355bc114136dfd4db37,
title = "A culture model to study neuron-Schwann cell-astrocyte interactions",
abstract = "In vitro models using Schwann cell and astrocyte co-cultures have been used to understand the mechanisms underlying the formation of boundaries between these cells in vivo. Schwann cell/astrocyte co-cultures also mimic the in vivo scenario of a transplant in a spinal cord injury site, thereby allowing testing of therapeutic approaches. In this chapter, we describe a triple cell culture system with Schwann cells, astrocytes, and neurons that replicates axon growth from a Schwann cell graft into an astrocyte-rich region. In vitro studies using this model can accelerate the discovery of more effective therapeutic combinations to be used along with Schwann cell transplantation after spinal cord injuries.",
keywords = "Astrocytes, Axon growth, Co-cultures, Glial barrier, Neurons, Schwann cells",
author = "Cerqueira, {Susana R.} and Lee, {Yee Shuan} and Bunge, {Mary Bartlett}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC.",
year = "2018",
doi = "10.1007/978-1-4939-7649-2_17",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "269--279",
booktitle = "Methods in Molecular Biology",
}