A crossover comparison of brotizolam aand temazepam in the treatment of insomnia

R. A. Dominguez, A. F. Jacobson, B. J. Goldstein, R. M. Steinbook

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Abstract

Twenty-three insomniac outpatients were treated with open-label temazepam after a 21-day double-blind study of brotizolam versus placebo, followed by a 7-day placebo/washout period. The dosage was 0.25 to 0.59 mg of brotizolam per night and 30 mg per night for temazepam. Global ratings reflecting the hypnotic efficacy of the treatment were obtained weekly. Both active drugs showed statistically significant efficacy compared with placebo but comparison of the two drug groups revealed that brotizolam was significantly more effective in the treatment of insomnia than temazepam.

Original languageEnglish
Pages (from-to)372-379
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume33
Issue number3 I
StatePublished - Jan 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dominguez, R. A., Jacobson, A. F., Goldstein, B. J., & Steinbook, R. M. (1983). A crossover comparison of brotizolam aand temazepam in the treatment of insomnia. Current Therapeutic Research - Clinical and Experimental, 33(3 I), 372-379.