A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system

John E Lewis, Laura Lantigua, Steven E. Atlas, Johanna Lopez, Armando J Mendez, Sharon Goldberg, Sacha Medici, Janet Konefal, Judi Woolger, Eduard Tiozzo, Karyem H. Aliffe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Type 2 diabetes mellitus is frequently unrecognized until complications appear. Diabetic autonomic neuropathy is one of the early complications of type 2 diabetes mellitus, resulting in autonomic nervous system (ANS) dysfunction. The purpose of this study was to determine the validity of ANS function indicators to screen for type 2 diabetes mellitus, as measured by the TM-Oxi and SudoPath system. Methods: All enrolled participants completed a basic sociodemographic and medical history questionnaire including current medications. Healthy controls (n = 25) underwent a 2-hour oral glucose tolerance test (OGTT) to evaluate glucose, insulin, and insulin C-peptide. Patients with type 2 diabetes mellitus (n = 24) were assessed with fasting plasma glucose (FPG) and glycosylated hemoglobin. The TM-Oxi and SudoPath system evaluation was completed by all subjects. Data were analyzed using SPSS 22. Frequency and descriptive statistics were calculated on all variables. The criterion for statistical significance was a = 0.05. Results: The twenty-five healthy controls had a mean age of 37.0 years. The twenty-four type 2 diabetes mellitus patients currently undergoing standard treatment had a mean age of 48.9 years. Based on the American Diabetes Association guidelines, we detected pre-diabetes in 4 subjects and diabetes in 1 subject, while all other subjects had normal FPG values. At 120 minutes, the correlations between the OGTT and cardiometabolic risk score (CMRS) were: r = 0.56 (p = 0.004) for glucose and r = 0.53 (p = 0.006) for insulin. At 120 minutes, the correlations between the OGTT and photoplethysmography index (PTGi) were: r = -0.56 (p = 0.003) for glucose and r = -0.41 (p = 0.04) for insulin. The CMRS, PTGi, and plethysmography total power index (PTGVLFi) differed significantly between the diabetes patients and healthy participants. The specificity and sensitivity for the CMRS, PTGi, and PTVLFi comparing the diabetes patients with healthy controls were high. Conclusion: The TM-Oxi and SudoPath system shows promise as a valid, convenient, and non-invasive screening method for type 2 diabetes mellitus. The ANS function and CMR indicators measured by this system may be useful in guiding diabetes and cardiovascular health screening, treatment, and monitoring.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Diabetes and Metabolic Disorders
Volume13
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Autonomic Nervous System
Type 2 Diabetes Mellitus
Photoplethysmography
Glucose
Glucose Tolerance Test
Insulin
Fasting
Plethysmography
Diabetic Neuropathies
C-Peptide
Glycosylated Hemoglobin A
Diabetes Complications
Healthy Volunteers
Guidelines
Sensitivity and Specificity
Health
Therapeutics
Formoterol Fumarate

Keywords

  • Autonomic nervous system
  • Cardiometabolic risk
  • Diabetic autonomic neuropathy
  • Glycosylated hemoglobin
  • Oral glucose tolerance test
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system. / Lewis, John E; Lantigua, Laura; Atlas, Steven E.; Lopez, Johanna; Mendez, Armando J; Goldberg, Sharon; Medici, Sacha; Konefal, Janet; Woolger, Judi; Tiozzo, Eduard; Aliffe, Karyem H.

In: Journal of Diabetes and Metabolic Disorders, Vol. 13, No. 1, 2014, p. 1-8.

Research output: Contribution to journalArticle

Lewis, JE, Lantigua, L, Atlas, SE, Lopez, J, Mendez, AJ, Goldberg, S, Medici, S, Konefal, J, Woolger, J, Tiozzo, E & Aliffe, KH 2014, 'A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system', Journal of Diabetes and Metabolic Disorders, vol. 13, no. 1, pp. 1-8. https://doi.org/10.1186/s40200-014-0118-x
Lewis, John E ; Lantigua, Laura ; Atlas, Steven E. ; Lopez, Johanna ; Mendez, Armando J ; Goldberg, Sharon ; Medici, Sacha ; Konefal, Janet ; Woolger, Judi ; Tiozzo, Eduard ; Aliffe, Karyem H. / A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system. In: Journal of Diabetes and Metabolic Disorders. 2014 ; Vol. 13, No. 1. pp. 1-8.
@article{ef08ee5d4bdc48dca886137b1bf2011b,
title = "A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system",
abstract = "Background: Type 2 diabetes mellitus is frequently unrecognized until complications appear. Diabetic autonomic neuropathy is one of the early complications of type 2 diabetes mellitus, resulting in autonomic nervous system (ANS) dysfunction. The purpose of this study was to determine the validity of ANS function indicators to screen for type 2 diabetes mellitus, as measured by the TM-Oxi and SudoPath system. Methods: All enrolled participants completed a basic sociodemographic and medical history questionnaire including current medications. Healthy controls (n = 25) underwent a 2-hour oral glucose tolerance test (OGTT) to evaluate glucose, insulin, and insulin C-peptide. Patients with type 2 diabetes mellitus (n = 24) were assessed with fasting plasma glucose (FPG) and glycosylated hemoglobin. The TM-Oxi and SudoPath system evaluation was completed by all subjects. Data were analyzed using SPSS 22. Frequency and descriptive statistics were calculated on all variables. The criterion for statistical significance was a = 0.05. Results: The twenty-five healthy controls had a mean age of 37.0 years. The twenty-four type 2 diabetes mellitus patients currently undergoing standard treatment had a mean age of 48.9 years. Based on the American Diabetes Association guidelines, we detected pre-diabetes in 4 subjects and diabetes in 1 subject, while all other subjects had normal FPG values. At 120 minutes, the correlations between the OGTT and cardiometabolic risk score (CMRS) were: r = 0.56 (p = 0.004) for glucose and r = 0.53 (p = 0.006) for insulin. At 120 minutes, the correlations between the OGTT and photoplethysmography index (PTGi) were: r = -0.56 (p = 0.003) for glucose and r = -0.41 (p = 0.04) for insulin. The CMRS, PTGi, and plethysmography total power index (PTGVLFi) differed significantly between the diabetes patients and healthy participants. The specificity and sensitivity for the CMRS, PTGi, and PTVLFi comparing the diabetes patients with healthy controls were high. Conclusion: The TM-Oxi and SudoPath system shows promise as a valid, convenient, and non-invasive screening method for type 2 diabetes mellitus. The ANS function and CMR indicators measured by this system may be useful in guiding diabetes and cardiovascular health screening, treatment, and monitoring.",
keywords = "Autonomic nervous system, Cardiometabolic risk, Diabetic autonomic neuropathy, Glycosylated hemoglobin, Oral glucose tolerance test, Type 2 diabetes mellitus",
author = "Lewis, {John E} and Laura Lantigua and Atlas, {Steven E.} and Johanna Lopez and Mendez, {Armando J} and Sharon Goldberg and Sacha Medici and Janet Konefal and Judi Woolger and Eduard Tiozzo and Aliffe, {Karyem H.}",
year = "2014",
doi = "10.1186/s40200-014-0118-x",
language = "English",
volume = "13",
pages = "1--8",
journal = "Journal of Diabetes and Metabolic Disorders",
issn = "2251-6581",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - A cross-sectional assessment to detect type 2 diabetes with endothelial and autonomic nervous system markers using a novel system

AU - Lewis, John E

AU - Lantigua, Laura

AU - Atlas, Steven E.

AU - Lopez, Johanna

AU - Mendez, Armando J

AU - Goldberg, Sharon

AU - Medici, Sacha

AU - Konefal, Janet

AU - Woolger, Judi

AU - Tiozzo, Eduard

AU - Aliffe, Karyem H.

PY - 2014

Y1 - 2014

N2 - Background: Type 2 diabetes mellitus is frequently unrecognized until complications appear. Diabetic autonomic neuropathy is one of the early complications of type 2 diabetes mellitus, resulting in autonomic nervous system (ANS) dysfunction. The purpose of this study was to determine the validity of ANS function indicators to screen for type 2 diabetes mellitus, as measured by the TM-Oxi and SudoPath system. Methods: All enrolled participants completed a basic sociodemographic and medical history questionnaire including current medications. Healthy controls (n = 25) underwent a 2-hour oral glucose tolerance test (OGTT) to evaluate glucose, insulin, and insulin C-peptide. Patients with type 2 diabetes mellitus (n = 24) were assessed with fasting plasma glucose (FPG) and glycosylated hemoglobin. The TM-Oxi and SudoPath system evaluation was completed by all subjects. Data were analyzed using SPSS 22. Frequency and descriptive statistics were calculated on all variables. The criterion for statistical significance was a = 0.05. Results: The twenty-five healthy controls had a mean age of 37.0 years. The twenty-four type 2 diabetes mellitus patients currently undergoing standard treatment had a mean age of 48.9 years. Based on the American Diabetes Association guidelines, we detected pre-diabetes in 4 subjects and diabetes in 1 subject, while all other subjects had normal FPG values. At 120 minutes, the correlations between the OGTT and cardiometabolic risk score (CMRS) were: r = 0.56 (p = 0.004) for glucose and r = 0.53 (p = 0.006) for insulin. At 120 minutes, the correlations between the OGTT and photoplethysmography index (PTGi) were: r = -0.56 (p = 0.003) for glucose and r = -0.41 (p = 0.04) for insulin. The CMRS, PTGi, and plethysmography total power index (PTGVLFi) differed significantly between the diabetes patients and healthy participants. The specificity and sensitivity for the CMRS, PTGi, and PTVLFi comparing the diabetes patients with healthy controls were high. Conclusion: The TM-Oxi and SudoPath system shows promise as a valid, convenient, and non-invasive screening method for type 2 diabetes mellitus. The ANS function and CMR indicators measured by this system may be useful in guiding diabetes and cardiovascular health screening, treatment, and monitoring.

AB - Background: Type 2 diabetes mellitus is frequently unrecognized until complications appear. Diabetic autonomic neuropathy is one of the early complications of type 2 diabetes mellitus, resulting in autonomic nervous system (ANS) dysfunction. The purpose of this study was to determine the validity of ANS function indicators to screen for type 2 diabetes mellitus, as measured by the TM-Oxi and SudoPath system. Methods: All enrolled participants completed a basic sociodemographic and medical history questionnaire including current medications. Healthy controls (n = 25) underwent a 2-hour oral glucose tolerance test (OGTT) to evaluate glucose, insulin, and insulin C-peptide. Patients with type 2 diabetes mellitus (n = 24) were assessed with fasting plasma glucose (FPG) and glycosylated hemoglobin. The TM-Oxi and SudoPath system evaluation was completed by all subjects. Data were analyzed using SPSS 22. Frequency and descriptive statistics were calculated on all variables. The criterion for statistical significance was a = 0.05. Results: The twenty-five healthy controls had a mean age of 37.0 years. The twenty-four type 2 diabetes mellitus patients currently undergoing standard treatment had a mean age of 48.9 years. Based on the American Diabetes Association guidelines, we detected pre-diabetes in 4 subjects and diabetes in 1 subject, while all other subjects had normal FPG values. At 120 minutes, the correlations between the OGTT and cardiometabolic risk score (CMRS) were: r = 0.56 (p = 0.004) for glucose and r = 0.53 (p = 0.006) for insulin. At 120 minutes, the correlations between the OGTT and photoplethysmography index (PTGi) were: r = -0.56 (p = 0.003) for glucose and r = -0.41 (p = 0.04) for insulin. The CMRS, PTGi, and plethysmography total power index (PTGVLFi) differed significantly between the diabetes patients and healthy participants. The specificity and sensitivity for the CMRS, PTGi, and PTVLFi comparing the diabetes patients with healthy controls were high. Conclusion: The TM-Oxi and SudoPath system shows promise as a valid, convenient, and non-invasive screening method for type 2 diabetes mellitus. The ANS function and CMR indicators measured by this system may be useful in guiding diabetes and cardiovascular health screening, treatment, and monitoring.

KW - Autonomic nervous system

KW - Cardiometabolic risk

KW - Diabetic autonomic neuropathy

KW - Glycosylated hemoglobin

KW - Oral glucose tolerance test

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84922976475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922976475&partnerID=8YFLogxK

U2 - 10.1186/s40200-014-0118-x

DO - 10.1186/s40200-014-0118-x

M3 - Article

AN - SCOPUS:84922976475

VL - 13

SP - 1

EP - 8

JO - Journal of Diabetes and Metabolic Disorders

JF - Journal of Diabetes and Metabolic Disorders

SN - 2251-6581

IS - 1

ER -